A model of experimental postnatal hyperbilirubinemia in the rat has been developed utilizing the heme precursor delta-aminolevulinic acid (ALA) to produce jaundice during a selective time period after birth. This time period is defined as that between 7 d postnatally, when the initial postpartum alterations of serum bilirubin and heme metabolism in the neonate have subsided, and 21 d, when the ...

The serum bilirubin level of Japanese newborn infants in their first few days is significantly higher than that in Caucasian newborn infants, suggesting that there might be genetic risk factors for the development of neonatal hyperbilirubinemia in the Japanese population. Recently, it has been reported that a variant TATA box in the promoter region of the bilirubin UDP-glucuronosyltransferase 1...

Background. Having its multisystemic effect СOVID-19 leads to liver disfunction. Objective. To assess the functional state of in patients with COVID-19 during periods circulation different SARS-CoV 2 strains. Material and methods. The object study was 180 who were hospitalized at Grodno Regional Infectious Diseases Clinical Hospital. divided into two groups: 1st group (n=51) - those examined Om...

OBJECTIVE The clinical significance of postoperative hyperbilirubinemia after heart transplantation has not been reported. Here, we sought to evaluate the incidence, risk factors, and prognosis of postoperative hyperbilirubinemia after heart transplantation. METHODS Between 1987 and 2005, 256 consecutive patients undergoing heart transplantation were studied prospectively. Postoperative hyper...

Although not endemic in Portugal, malaria remains a potentially fatal imported disease. Besides the delay diagnosis and initiation of treatment, other factors have probably contributed to increase cases its severe form: travel areas, absence immunity, inappropriate use prophylactic measures, gradual resistance Plasmodium antimalarials. The classic form is usually caused by falciparum may presen...

BACKGROUND Do colorectal cancer patients with hyperbilirubinemia and liver metastases benefit from chemotherapy? METHODS/RESULTS This study entailed a review of 3,019 consecutive patients with colorectal cancer. Within this cohort, 20 met the study's a priori selection criteria, which included a new diagnosis of colorectal cancer, no prior therapy, and a total bilirubin of ≥3.0 mg/dL. All 20 ...

Despite efforts to eliminate permanent and irreversible brain damage due to bilirubin encephalopathy and kernicterus, these conditions continue to accompany us into the third millennium. This phenomenon occurs not only in developing countries with emerging medical systems, but in Westernized countries as well. Comprehensive guidelines to detect newborns with jaundice and treat those in whom hyp...