DESPITE THE NUMEROUS procedures available for the determination of uric acid, their clinical use remains subject to considerable error. A simple precise method for routine clinical use is desirable since determination of the level of serum uric acid is an important criterion for the diagnosis of gout. Excellent critical reviews of the available methods have been published (1, 2, 3). The current...

BACKGROUND Hyperuricemia is associated with obesity. The visceral adiposity and subcutaneous adiposity may be associated with the differential metabolic risk, and the distribution of abdominal adipose tissue was significantly altered in people with type 2 diabetes mellitus (DM) compared to healthy people. Our study was performed to determine to the association between the regional abdominal adi...

UNLABELLED We examined the relation of serum creatinine and uric acid to mortality and cardiovascular disease in older (aged >/=60 years) Chinese patients with isolated systolic hypertension (systolic/diastolic blood pressure >/=160/<95 mm Hg). We used Cox regression to correlate outcome with baseline serum creatinine and uric acid measured in 1880 and 1873, respectively, of the 2394 patients e...

The recent article describing a positive association between serum uric acid and several inflammatory markers in the InCHIANTI study addresses the issue of whether uric acid is an independent cardiovascular risk factor. Uric acid is an antioxidant and appears to contribute to salutary immune reactions, but the cardiovascular significance of rises in its serum level remains poorly understood. I ...

The aim of this study was to investigate whether serum uric acid levels are significantly associated with the parameters that contribute to the metabolic syndrome in a rural community from Iasi County, Romania. We observed that the components associated most with the serum levels of uric acid were body mass index, triglycerides, waist circumference and hip circumference. Significant correlation...

The aim of the study was to investigate the effect of theophylline on serum magnesium (Mg) and uric acid levels in children with asthma and the relationship between hyperuricemia and serum nitric oxide metabolite levels (NO2) in the same group of patients. Patients and methods: Forty four known asthmatic children who has been referred to pediatrics clinic of the National Research CenterEgypt. T...

BACKGROUND Determination of serum uric acid concentrations and role in risk of metabolic syndrome (MS) were investigated in 1877 participants in a cross-sectional population-based study including a brief follow-up. METHODS The MS was identified by modified criteria of the Adult Treatment Panel III, and coronary heart disease (CHD) by clinical findings and Minnesota coding of resting electroca...

Correspondence to: Richard J Johnson. University of Colorado Anschutz Medical. Campus, Aurora, CO, 80045, USA. E-mail: richard.johnson@ ucdenver.edu Serum uric acid has recently received attention as a potential biomarker independently predicting the development of hypertension, diabetes mellitus, and chronic kidney disease.1-3 Elevated serum uric acid has also been reported to predict developm...

OBJECTIVE We previously described a cross-sectional association between serum uric acid and reduced glomerular filtration rate (GFR) in nonproteinuric patients with type 1 diabetes. Here, we prospectively investigated whether baseline uric acid impacts the risk of early progressive renal function loss (early GFR loss) in these patients. RESEARCH DESIGN AND METHODS Patients with elevated urina...

Uric acid is a risk factor of cardiovascular disease, as well as a major natural antioxidant, prohibiting the occurrence of cellular damage. The relation between uric acid and cognitive decline, in which both vascular mechanisms and oxidative stress are thought to play a role, is unknown. Therefore we assessed the relation between serum uric acid levels and the risk of subsequent dementia in a ...