Pyrazole treatment to induce cytochrome P-450 2E1 (CYP2E1) was recently shown to cause liver injury in ob/ob mice but not in lean mice. The present study investigated the effects of S-adenosyl-l-methionine (SAM) on the CYP2E1-dependent liver injury in ob/ob mice. Pyrazole treatment of ob/ob mice for 2 days caused necrosis, steatosis, and elevated serum transaminase and triglyceride levels compa...

OBJECTIVE To investigate cardiac complications in infectious mononucleosis patients and to associate them with biochemical and immunological parameters, as well as with spleen ultrasound findings. DESIGN Cross-sectional study with follow-up. SETTING Tertiary care pediatric unit, in the city of Thessaloniki, Greece. PARTICIPANTS AND INTERVENTIONS Twenty-five children (15 boys, aged 1-11.6...

Introduction: Nowadays, a significant number of children with acute leukemia can be cured. Iron overload, related to blood transfusions and its long-term complications, remains problem. Elevated ferritin concentration is often observed in this group. The aim study was evaluate the prognostic value serum on outcomes treated for leukemia. Material: We studied 71 patients lymphoblastic (ALL) or my...

Marked activity of cobalt-activated acylase was found in the sera of 33 of 37 patients with acute toxic hepatitis due to poisoning with either amanita mushrooms or chemicals. The activity of the enzyme showed a positive correlation with that of serum transaminases, reached the highest levels on the patient's admission to hospital and within a few days fell rapidly to undetectable levels. Slight...

Aim : To study the curative effect of Sapindus mukorossi and Rheum emodi extracts in CCl4 induced liver cirrhosis in male rats. Methods : The dried powder of S. mukorossi & R. emodi was extracted successively with petroleum ether, benzene, chloroform and ethanol and concentrated in vacuum. The curative effect of the extracts of the fruit pericarp of S. mukorossi and rhizomes of R. emodi was stu...