Effect of SI level and saturation of TIBC on the induction of ferritin in erythroid cells was investigated in rats, guinea pigs, and rabbits. Evidence presented indicates that species difference and serum iron level are important factors in induction of micropinocytotic ferritin in developing erythroid cells: (1) Micropinocytotic ferritin was occasionally seen in erythroblasts of control guinea...

Abstract Background Iron deficiency anemia (IDA) is one of the most common leading global health problems, which could cause extreme fatigue, chest pain, headache, and even neurodevelopment deterioration in children. Traditionally, assessing serum ferritin, transferrin, iron are tools to diagnose IDA. However, a high false-positive rate these conventional biomarkers might be observed due inflam...

Effect of SI level and saturation of TIBC on the induction of ferritin in erythroid cells was investigated in rats, guinea pigs, and rabbits. Evidence presented indicates that species difference and serum iron level are important factors in induction of micropinocytotic ferritin in developing erythroid cells: (1) Micropinocytotic ferritin was occasionally seen in erythroblasts of control guinea...

2,4,6-Tripyridyl-s-triazine (TPTZ) is a color reagent for ferrous ion in the pH range 2 to 10,when ascorbic acid is used as the reducing agent. In this range TPTZ and ferrous ion combine in the ratio of two to one. Tris buffer is commonly used to maintain an alkaline pH, but it reacts with other reducing agents, rendering them ineffective. These observations suggested a method for the joint det...

Severe anemia, which commonly occurs in patients with chronic renal failure, usually results from deficient production of erythropoietin. Other causative factors, i.e., iron deficiency, frequently contribute to the anemia, especially in patients on chronic hemodialysis. This has led to the almost routine use of intravenous iron-dextran. Recently, recombinant erythropoietin has been used in the ...

OBJECTIVE The study was carried out to understand the pathogenesis of hematological dyscrasias and cytotoxicity following administration of both purified and commercially available form of Clozapine in an animal model. METHODS The Albino Sprague Dawley rats (n=30) with an average weight of 180g were taken and divided into three groups. Haematological parameters including haemoglobin, haematoc...

Iron-deficiency anemia is the nutritional deficiency most frequently occurring throughout the world, which manifests as a complex systemic disease involving all cells, affecting enzyme activities and modifying protein synthesis. In view of these considerations, the objective of the present study was to determine the effects of iron-deficiency anemia on disaccharidases and on the epithelial morp...

Although subjective global assessment (SGA) is a widely used tool for nutritional investigation, the scores are dependent on the inspectors' subjective opinions, and there are only few studies that directly assessed the usefulness of SGA and modified SGA in incident peritoneal dialysis (PD) patients. A total of 365 incident PD patients between 2009 and 2015 were enrolled and measured with SGA a...

BACKGROUND AND AIM Pathogenesis of Febrile Convulsion (FC) is unknown but some elements and genetic predispositions have been considered in the top list. This case-control study was designed to compare some trace elements in paediatrics who were admitted with FC and those in febrile ones without seizure attacks at an academic hospital in northeast of Iran. MATERIAL AND METHODS This case-contr...

Introduction: One of the functions kidneys is production erythropoietin, a signaling molecule that stimulates red blood cells, in response to reduced oxygen levels blood. In chronic kidney disease, there disturbance erythropoietin. Several previous studies have linked index erythropoietin resistance mortality patients with disease. The study aimed correlate between (ERI) and Mortality regular h...