Prostate specific antigen (PSA) is the common biomarker for prostate cancer (PCa). However, its lack of specificity to differentiate PCa from benign disorders stimulates search alternative biomarkers improve clinical management patients. Different studies have described changes in core-fucosylation level PSA between patients and healthy controls. To exploit these findings, we adapted an impedim...

in this study 71 head of conceiving ewe and their progeny (91 head) from the flock of lori-bakhtiari sheep (360 head), in sholi station were randomly selected to determine the relationship between the immunoglobulin (igg) concentration in the ewe's serum and colostrum, and lamb's serum. ewe blood sample, colostrum of ewe and blood of the lamb was taken 2 weeks before parturition, 1 to 8 hours a...

perforin(p) is the primary mediator of short term cytotoxicity, it is accumulated in response to proinflammatory  cytokines and stored in t lymphocyte , nk cells and nkt cells are released upon activation. perforin is a prototypical cytotoxic molecule involved in cell mediated immunity against various pathogens , alloantigens and particularly different tumors.the purpose of this study was to de...

background: immunoradiometric assay is one of the most common and precise methods for determination of prostate specific antigen (psa) in clinical laboratories. usual use of human serum in routine assays has many disadvantages such as easy contamination and precipitation, instability and unavailability. thus in order to avoid these problems the artificial matrix was used which acts similar to h...

Background: Prostate cancer is the second form of cancer among men worldwide. For early cancer detection, we should identify tumors in initial stages before the physical signs become visible. The present study aims to evaluate the diagnostic value of cell-free DNA (cfDNA), its comparison with prostate-specific antigen (PSA) level in prostate cancer screening and also in patients with localized ...

We report a case of prostate cancer in 34 year old man presenting with generalized lymphadenopathy mimicking malignant lymphoma without any urinary symptoms. Lymph node biopsy revealed metastatic adenocarcinoma and immunohistochemical stain was strongly positive to prostate antigen (PSA). Serum PSA level was also markedly elevated. Transrectal ultrasonogram showed mild enlargement in right lobe...

OBJECTIVES To determine the incidence and magnitude of the rapid increase in the serum PSA (riPSA) level after high-intensity focused ultrasound (HIFU) therapy for prostate cancer, and its correlation with clinical factors. METHODS A total of 176 patients with localized prostate cancer underwent HIFU therapy. Serum riPSA was determined on the basis of the same criteria as those for "PSA bounc...

Rheumatoid (RA) and Psoriatic arthritis (PsA) are characterized by extensive synovitis resulting in bone destruction in both diseases and new bone formation in PsA. Objective: This prospective study analyzed interleukin (IL)-6, IL-17, IL-23, tumor necrosis factor (TNF)-α serum and synovial fluid (SF) levels and osteoprotegerin (OPG), bone-specific alkaline phosphatase (BAP) and D-vitamin (D-Vit...

BACKGROUND BPSA is a "benign" form of free prostate-specific antigen (PSA) that is increased in prostate transition zone tissues of men with pathologic benign prostatic hyperplasia (BPH). We developed an immunoassay to determine the concentration of BPSA in the serum of men with BPH. METHODS The BPSA antigen was purified by HPLC, and murine monoclonal antibodies were prepared by standard meth...