Sclerostin, an inhibitor of bone formation, has emerged as a potential negative regulator glucose homeostasis. We aimed to investigate if serum sclerostin associates with insulin sensitivity, beta cell function, prediabetes or metabolic syndrome in healthy men. Serum was measured basal and insulin-stimulated samples from 526 men without diabetes the RISC cohort study. An OGTT performed at basel...

The purpose of this study was to measure serum levels insulin-like growth factor-binding protein (IGFBP7), Insulin-like Growth Factor 1 (IGF-1), Hormone (GH), Interleukin 6 (IL-6) and insulin in acromegaly patients healthy controls. group had 60 patients, while the population 30 people who never before. concentration IGFBP7, IGF-1, GH, IL-6, were determined. results present indicate that IGFBP7...

Obesity was associated with high serum vaspin concentrations and increased vaspin mRNA expression in human adipose tissue , insulin resistance, and type II diabetes. However, the mechanisms how vaspin secretion may be linked to deterioration of glucose metabolism and insulin sensitivity are not understood. The aim of this work is to explore the effect of dietary regimen for 6 months on serum va...

Background: Chemerin is and adipokine produced and secreted by adipose tissue and is associated with functions such as insulin resistance, inflammation, and blood pressure regulation. The purpose of the present study was the determination of serum chemerin level in an Iranian population with metabolic syndrome and its comparison with healthy individuals. Materials and Methods: The study subj...

Objective: Obesity is a factor in the development of insulin resistance and type 2 diabetes. Obesity contributes a wide variety of metabolic changes such as insulin resistance. The insulin signal mechanism to intra-cells occurs in insulin resistance, primarily in adipose tissue cells, which can be appropriate targets for therapeutic approaches by recognizing the proteins in this pathway. The st...

Due to the range of its constituents, colostrum has been considered as a supplement for various diverse purposes. This study was conducted to examine the effect of supplementary bovine colostrum on serum malondialdehyde (MDA), antioxidant activity (AOA) and glucose in a diabetic rodent model. Sixty male Wistar rats were divided into 10 groups of six rats each for 40 days as follows: non-diabeti...

objective: crocinisa saffron constituent with a potent anti-oxidant activity. the present study investigated the effects of crocin and insulin treatments (alone or in combination) on cardiac function and pathology in diabetic rats. materials and methods: diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (stz, 50 mg/kg). thereafter, crocin (5, 10 and 20 mg/kg, i.p.), sub...

objective: worldwide, diabetes mellitus (dm) is an ever-increasing metabolic disorder. a promising approach to the treatment of dm is the implantation of insulin producing cells (ipc) that have been derived from various stem cells. culture conditions play a pivotal role in the quality and quantity of the differentiated cells. in this experimental study, we have applied various culture condition...