Gentamicin is an important aminoglycoside antibiotic. However its use is limited to serious and life threatening gram negative infections, because of its high nephrotoxicity potential in patients. There are reports that safranal, the active ingredient of saffron with antioxidant properties, exerts protective effect against ischemic injuries occurred by certain nephrotoxins including gentamicin....

The V2 receptor antagonist tolvaptan has been approved for volume control in heart-failure patients in Japan. Tolvaptan increases renal blood flow, and so the present study was designed to ascertain whether tolvaptan could be a useful diuretic for volume control without reducing residual renal function (RRF) in peritoneal dialysis (PD) patients. Tolvaptan was administered in 15 PD patients (15 ...

The aim of the present investigation was to investigate the nephro-protective activity of fruits extracts of Rubus ellipticus (Smith) at a dose of 200 mg/kg body weight on acetaminophen (APAP) induced naphro-toxicity in male albino rats. APAP significantly increased the levels of serum creatinine, serum urea, blood urea nitrogen and kidney weight while the volume of urine reduced. The pet.ether...

Introduction.Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stage disease.Patients with chronic kidney disease face with uremic toxins and hyperkalemia. Also fluid overload in CKD patients is associated with rapid decline in kidney function.Lactulose is a hyper osmotic agent and as a prebioticplays an important role in regulating serum urea...

hemiscorpius lepturus is medically important scorpion species present in the south and southwest part of iran, causing morbidity and mortality in children and adults. unlike other scorpions studied so far, the venom of h. lepturus is highly cytotoxic, that can be a reason for its complexity in clinical manifestations in patients stung by this scorpion. scarce studies showed the mechanism involv...

Cystone, a polyherbal Ayurvedic preparation, was found to protect rats partially but significantly against cisplatin-induced renal toxicity, when given intraperitoneally 1 hour before cisplatin. At 500 and 1000 μg/ml, it also inhibited lipid peroxidation induced by cisplatin in renal cortical slices by 62.7 and 71.6% respectively. The rats pretreated with Cystone (1000 mg/kg i.p.) had significa...

the physiological effects of a diet free of meat and eggs were studied. fifteen adult lacto-vegetarians were matched with non-vegetarian individuals by age, sex, body weight and height. a two-week dietary record was secured from each individual. the food consumed over a 48-hour period was measured. venous blood samples were taken from each individual for determination of serum total protein, ur...

OBJECTIVE This study aims to explore the protective effect mechanism of 2-deoxy-D-glucose on nephrotoxicity of cyclosporin A in vivo. METHOD Renal toxicity of SD rats model induced by CsA was established. Serum creatinine, blood urea nitrogen, urine NAG, GSH and MDA were determined and the histopathological changes of rat renal cortex were observed to explore the protective effects of 2-DG on...

conclusions therefore, our results suggest that although administration of 300 mg/kg of calendula officinalis extract showed salutary effects on anti-oxidant profile, yet its protective effects on anti-diabetic and regenerative properties on nephropathy were ambiguous and require more investigations. background chronic hyperglycemia leads to microvascular and macrovascular complications such as...