نتایج جستجو برای: sertraline
تعداد نتایج: 1653 فیلتر نتایج به سال:
The effect of the selective serotonin reuptake inhibitor (SSRI) sertraline 200 mg/day on the metabolism of intravenously administered tolbutamide was examined in a randomised nonblinded parallel-group study in 25 healthy male volunteers. There was a small but statistically significant decrease (16%) in the clearance of tolbutamide in patients receiving the maximum recommended dosage of sertrali...
a 67-year-old male suffering from depressive symptomatology was admitted to the inpatient clinic at firat university school of medicine; and his psychiatric evaluation revealed major depressive episode according to dsm-iv. he developed chest discomfort, chest pain and shortness of breath of acute onset accompanying pulseless ventricular tachycardia (vt) leading to cardiac arrest following sertr...
Sir, Sertraline (Zoloft1) is a new selective inhibitor of serotonin re-uptake. This family of antidepressant drugs is considered to be safe, and cutaneous adverse reactions have rarely been reported (1). We report here a patient who developed StevensJohnson syndrome (SJS) after starting treatment with sertraline (Zoloft1). A 96-year-old woman was admitted with a cutaneous and mucosal eruption. ...
CONTEXT Despite the high prevalence, chronicity, and associated comorbidity of posttraumatic stress disorder (PTSD) in the community, few placebo-controlled studies have evaluated the efficacy of pharmacotherapy for this disorder. OBJECTIVE To determine if treatment with sertraline hydrochloride effectively diminishes symptoms of PTSD of moderate to marked severity. DESIGN Twelve-week, doub...
Depression, a bewildering and burdensome illness, is one of the commonest psychiatric diseases. It is expected to be the second leading contributor to Global Disease Burden by 2020. The objective of the study was to determine the effect of nifedipine on the responses of imipramine, sertraline and furosemide in the forced swim test (FST) and tail suspension test (TST) in mice. Groups of mice wer...
BACKGROUND Conventional meta-analyses have shown inconsistent results for efficacy of second-generation antidepressants. We therefore did a multiple-treatments meta-analysis, which accounts for both direct and indirect comparisons, to assess the effects of 12 new-generation antidepressants on major depression. METHODS We systematically reviewed 117 randomised controlled trials (25 928 partici...
Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial.
BACKGROUND Depression is a common and costly comorbidity in dementia. There are very few data on the cost-effectiveness of antidepressants for depression in dementia and their effects on carer outcomes. AIMS To evaluate the cost-effectiveness of sertraline and mirtazapine compared with placebo for depression in dementia. METHOD A pragmatic, multicentre, randomised placebo-controlled trial w...
Chronic stress induces morphological changes in the neurons of several brain regions, including medial prefrontal cortex (mPFC). This region is involved in variety of behavioral tasks, including learning and memory. Our previous work showed that stress impaired function. The present work extends the earlier work to study mPFC in stressed and non-stressed rats with or without sertraline or curcu...
Mild depressive syndromes are highly prevalent among primary-care patients. Evidence-based treatment recommendations need to be derived directly from this diagnostically heterogeneous group. The primary aim was to assess the efficacy of sertraline and cognitive-behavioural group therapy for treatment of depressed primary-care patients, the secondary aim was to evaluate if receiving treatment ac...
BACKGROUND The prevalence of trauma-related psychiatric disorders is high among refugees. Despite this, little is known about the effect of pharmacological treatment for this patient group. The objective of the present study was therefore to examine differences in the effects of venlafaxine and sertraline on Post-Traumatic Stress Disorder (PTSD), depression and functional impairment in trauma-a...
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