نتایج جستجو برای: sertoli cell condition medium

تعداد نتایج: 2157061  

Journal: :Turkiye Klinikleri Journal of Case Reports 2019

2013
Gerard A. Tarulli Peter G. Stanton Kate L. Loveland Ewa Rajpert-De Meyts Robert I. McLachlan Sarah J. Meachem

It is widely held that the somatic cell population that is responsible for sperm development and output (Sertoli cells) is terminally differentiated and unmodifiable in adults. It is postulated, with little evidence, that Sertoli cells are not terminally differentiated in some phenotypes of infertility and testicular cancer. This study sought to compare markers of Sertoli cell differentiation i...

2005
James A. MacLean Mingang A. Chen Chad M. Wayne Shirley R. Bruce Manjeet Rao Marvin L. Meistrich Carol Macleod Miles F. Wilkinson

Cell Type Specificity of Rhox Gene Expression in Testes To identify the cell types in the testis that express the Rhox genes, we purified testicular cell fractions enriched for Sertoli and interstitial (e.g., Leydig) cells. Although it is not possible to generate entirely pure populations of these cell types, our fractions were substantially enriched, based on the relative levels of Sertoli and...

2013
Fei Pan Lifeng Chi Stefan Schlatt

Morphogenesis of tubular structures is a common event during embryonic development. The signals providing cells with topographical cues to define a cord axis and to form new compartments surrounded by a basement membrane are poorly understood. Male gonadal differentiation is a late event during organogenesis and continues into postnatal life. The cellular changes resemble the mechanisms during ...

Journal: :Endocrinology 1999
N Atanassova C McKinnell M Walker K J Turner J S Fisher M Morley M R Millar N P Groome R M Sharpe

This study aimed to identify the mechanism(s) for impairment of spermatogenesis in adulthood in rats treated neonatally with estrogens. Rats were treated (days 2-12) with 10, 1, or 0.1 microg diethylstilbestrol (DES), 10 microg ethinyl estradiol (EE), 10 mg/kg of a GnRH antagonist (GnRHa), or vehicle and killed in adulthood. DES/EE caused dose-dependent reductions in testis weight, total germ c...

2013
Reza Narenji Sani Parviz Tajik Mohammad Hassan Yousefi Mansoureh Movahedin Babak Qasemi-Panahi Shiva Shafiei Mahmood Ahmadi Hamedani

The complex process of spermatogenesis is regulated by various factors. Studies on spermatogonial stem cells (SCCs) have provided very important tool to improve herd genetic and different field. 0.2 to 0.3 percent of total cells of seminiferous tubules is consist of spermatogonial stem cells. To investigate and biomanipulation of these cells, proliferation and viability rate of cells should be ...

2015
Xiaopeng Hu Zhenzhou Tang Yang Li Wensheng Liu Shuang Zhang Bingyan Wang Yingpu Tian Yinan Zhao Hao Ran Wenjie Liu Gen-Sheng Feng Jianwei Shuai Haibin Wang Zhongxian Lu

The male's ability to reproduce is completely dependent on Sertoli cells. However, the mechanisms governing the functional integrity of Sertoli cells have remained largely unexplored. Here, we demonstrate that deletion of Shp2 in Sertoli cells results in infertility in mice. In Shp2 knockout mice (SCSKO), a normal population of Sertoli cells was observed, but the blood-testis barrier (BTB) was ...

Journal: :The Journal of endocrinology 2006
P Sluka L O'Donnell J R Bartles P G Stanton

Spermatogenesis is dependent on the ability of Sertoli cells to form mature junctions that maintain a unique environment within the seminiferous epithelium. Adjacent Sertoli cells form a junctional complex that includes classical adherens junctions and testis-specific ectoplasmic specialisations (ES). The regulation of inter-Sertoli cell junctions by the two main endocrine regulators of spermat...

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