This short review addresses immune functions of platelet serotonin. Platelets transport serotonin at a high concentration in dense granules and release it upon activation. Besides haemostatic, vasotonic and developmental modulation, serotonin also influences a variety of immune functions (mediated by different serotonin receptors). First, platelet serotonergic effects are directed against invad...

Aim of the research is to show developing legitimacy APUD-system lungs in pre and post ontogenesis. Condition neuroendocrine apparatus on rabbits was studied during fetal embryogenesis inner development after 1-180 days birth. Duration chosen according their changing afterbirth features as physiological function organism; selected periods newborn stage, enlightenment, complication locomotion, p...

Serotonin is an important neuromessenger used in a variety of signaling pathways throughout the animal kingdom. In insects, serotonin has been demonstrated to mediate feeding and feeding-related behaviors. In this study, serotonin antibody was localized in cells and processes throughout the central nervous system (CNS) and midgut of female horse fly Tabanus nigrovittatus Macquart. In the CNS, i...

Treatment of mice bearing the P-815 aseites mast-cell neoplasm produced biochemical and morphologie alterations in the cell population. The metachromasia of cells increased concon fitantly with a rise in serotonin content, while the histamine content of cells remained unchanged. The urinary excretion of 5-hydroxyindoleacetic acid was enhanced, and serotonin was excreted in large amounts in the ...

OBJECTIVE Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hypertension (PAH). We hypothesize that in PASMCs, serotonin induces oxidative stress through NADPH-oxidase-derived ROS generation and reduced Nrf-2 (nuclear factor [erythroid-derived 2]-like 2) antioxidant syste...

To understand the development of serotonergic neurons in vertebrates, we used zebrafish as a model system. In this study we cloned two cDNAs (complementary DNAs) coding for serotonin transporter (SERT) from the zebrafish, named serta and sertb. The serta cDNA encodes a protein of 693 amino acids and showed high level of sequence identity with rat and human SERTs. In situ hybridization showed se...