نتایج جستجو برای: serial resistance
تعداد نتایج: 431177 فیلتر نتایج به سال:
Antibiotic-resistant strains of Escherichia coli and, to a lesser extent, Klebsiella-Enterobacter were common in serial samples of the normal intestinal flora of healthy young adults in Thailand, and the resistance often was to multiple drugs and was transferable. Antibiotic administration promoted dominance of the flora by drug-resistant organisms regardless of the drug regimen and the predrug...
New antifolate-resi slant sublines of mouse leukemia L1210 have been developed. Dihydrofolate reductase activities were determined during early stages of increasing resistance to the folate antagonists. A daily dosage level of 0.75 mg amethopterin/kg used to develop subline FR-1 yielded tumor cells with a tenfold increase of enzyme within three serial transplants. When a new selective influence...
The recessive gene rymv-1, responsible for the high resistance of Oryza sativa 'Gigante' to Rice yellow mottle virus (genus Sobemovirus), was overcome by the variant CI4*, which emerged after serial inoculations of the non-resistance-breaking (nRB) isolate CI4. By comparison of the full-length sequences of CI4 and CI4*, a non-synonymous mutation was identified at position 1729, localized in the...
The liver may regulate glucose homeostasis by modulating the sensitivity/resistance of peripheral tissues to insulin, by way of the production of secretory proteins, termed hepatokines. Here, we demonstrate that selenoprotein P (SeP), a liver-derived secretory protein, causes insulin resistance. Using serial analysis of gene expression (SAGE) and DNA chip methods, we found that hepatic SeP mRNA...
The antibiotic sensitivity of the individual organisms of a bacterial population was determined to study the comparative rates of development of resistance of Staphylococcus aureus to novobiocin, tetracycline, and to a combination of these antibiotics. Serial subculture of S. aureus with the combination of novobiocin-tetracycline (N-T 2.5:1; the ratio in serum of patients dosed with Panalba) sh...
Weiss, Emilio (Naval Medical Research Institute, Bethesda, Md.) and Harry R. Dressler. Properties of quinoxaline oxide-resistant Rickettsia typhi. J. Bacteriol. 83:415-417. 1962.-An effort was made to apply to the Wilmington strain of Rickettsia typhi the observation that in certain strains of rickettsiae and viruses of the psittacosis group quinoxaline oxide resistance is easily obtained and i...
TR-700 (torezolid), the active moiety of the novel oxazolidinone phosphate prodrug TR-701, is highly potent against gram-positive pathogens, including strains resistant to linezolid (LZD). Here we investigated the potential of Staphylococcus aureus strains ATCC 29213 (methicillin-susceptible S. aureus [MSSA]) and ATCC 33591 (methicillin-resistant S. aureus [MRSA]) to develop resistance to TR-70...
Epithelial ovarian cancer (EOC) is the most prevalent form of ovarian cancer and has the highest mortality rate. Novel insight into EOC is required to minimize the morbidity and mortality rates caused by recurrent, drug resistant disease. Although numerous studies have evaluated genome instability in EOC, none have addressed the putative role chromosome instability (CIN) has in disease progress...
To elucidate whether tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia is associated with characteristic genomic alterations, we analyzed DNA samples from 45 TKI-resistant chronic myeloid leukemia patients with 250K single nucleotide polymorphism arrays. From 20 patients, matched serial samples of pretreatment and TKI resistance time points were available. Eleven of the 45 ...
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