نتایج جستجو برای: sep pak cartridge
تعداد نتایج: 10617 فیلتر نتایج به سال:
RATIONALE Excessive recruitment of polymorphonuclear leukocytes (PMNs) to the lung promotes acute lung injury (ALI). Chemokine receptors and adhesion molecules initiate leukocyte-endothelial interactions, but mediators of PMN migration through the alveolo-capillary membrane remain to be identified. p21-Activated kinase (PAK) is an effector of small GTPases and has been implicated in cell migrat...
P21-activated kinases (PAK) participate in a variety of important cellular activities, such as cytoskeleton remodeling, cell migration, cell cycle regulation, and apoptosis or survival. PAK also has an important impact on brain development, neuronal differentiation, and regulation of synaptic plasticity in the nervous system. PAK abnormalities result in diseases including cancer, Parkinson's di...
The p21-activated kinase(Pak) 2 undergoes rapid autophosphorylation/activation in neutrophils stimulated with a variety of chemoattractants (e.g., fMLP). Phosphorylation within the activation loop (Thr(402)) and inhibitory domain (Ser(141)) is known to increase the activity of Pak in vitro, whereas phosphorylation within the Nck (Ser(20)) and Pak-interacting guanine nucleotide exchange factor (...
عفونت از بیماری های بسیار شایع در کشورهای درحال توسعه می باشد و دستیابی به یک روش دقیق و سریع جهت تشخیص به موقع آن کمک بسیاری در درمان مناسب می باشد. هدف از این پروژه، دستیابی به یک روش تصویربرداری برای تعیین محل دقیق عفونت در بدن می باشد. اگرچه تصویربرداری از عفونت با گالیم سیترات در حال حاضر موجود می باشد ولی به دلیل مختص نبودن? کمک زیادی به تشخیص عفونت نمی نماید. انجام اسکن با سیپروفلوکساسین...
objective: infection control is one of the important aspects in dentistry. oral and maxillofacial surgery is one of the most sensitive fields in dentistry in which infection control is important a sterile surgical set is imperative. manufacturers only guarantee the sterility of the anesthetic not the sterility of its outer surface. they recommend alcohol to sterile the outer surface (especially...
Trio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila
Correct pathfinding by Drosophila photoreceptor axons requires recruitment of p21-activated kinase (Pak) to the membrane by the SH2-SH3 adaptor Dock. Here, we identify the guanine nucleotide exchange factor (GEF) Trio as another essential component in photoreceptor axon guidance. Regulated exchange activity of one of the two Trio GEF domains is critical for accurate pathfinding. This GEF domain...
Here, we show that postsynaptic p21-activated kinase (Pak) signaling diverges into two genetically separable pathways at the Drosophila neuromuscular junction. One pathway controls glutamate receptor abundance. Pak signaling within this pathway is specified by a required interaction with the adaptor protein Dreadlocks (Dock). We demonstrate that Dock is localized to the synapse via an Src homol...
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modeling, mass spectrometry-based quantitation of network components, and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that a network containing Rac1, RhoA, and PAK family kinases can produce bista...
Disturbed blood flow induces inflammatory gene expression in endothelial cells, which promotes atherosclerosis. Flow stimulates the proinflammatory transcription factor nuclear factor (NF)B through integrinand Rac-dependent production of reactive oxygen species (ROS). Previous work demonstrated that NFB activation by flow is matrix-specific, occurring in cells on fibronectin but not collagen. A...
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