This study assessed reliability of auditory sensory gating in young infants from 1-4 months of age using a paired-click paradigm in which auditory 'clicks' were presented at an interstimulus interval of 500 ms. Evoked potential component P1 was measured during periods of active sleep on two different occasions. Amplitudes, latencies, and ratio of the evoked potentials to each of the auditory cl...

The N2pc component of the event-related potential (ERP) is an index of visual-spatial attention. It is not clear whether the N2pc reflects pure top-down attentional activity or an interaction of top-down activity with bottom-up sensory activity. Here, we manipulated stimulus intensity of the items composing the target display. Although the amplitude of the P1 component increased monotonically w...

Bovine herpesvirus 1 (BHV-1) infection induces clinical symptoms in the upper respiratory tract, inhibits immune responses, and can lead to life-threatening secondary bacterial infections. Following acute infection, BHV-1 establishes latency in sensory neurons within trigeminal ganglia, but stress can induce reactivation from latency. The latency-related (LR) RNA is the only viral transcript ab...

2 Varicella-zoster virus (VZV) is a human alphaherpesvirus that infects sensory ganglia 3 and reactivates from latency to cause herpes zoster. VZV replication was examined in human 4 dorsal root ganglia (DRG) xenografts in mice with severe combined immunodeficiency using 5 multiscale correlative immunofluorescence and electron microscopy (IF-EM). These 6 experiments showed the presence of VZV g...

Bovine herpesvirus 1 (BHV-1), like other members of the Alphaherpesvirinae subfamily, establishes latency in sensory neurons. The virally encoded latency-related RNA (LR-RNA) is expressed abundantly in latently infected sensory neurons and encodes several proteins, including ORF2. An LR mutant virus with stop codons at the amino terminus of ORF2 does not reactivate from latency after treatment ...

Previous experience allows the brain to predict what comes next. How these expectations affect conscious experience is poorly understood. In particular, it is unknown whether and when expectations interact with sensory evidence in granting access to conscious perception, and how this is reflected electrophysiologically. Here, we parametrically manipulate sensory evidence and expectations while ...

In the environments where the source nodes are close to one another and generate a lot of sensory data traffic with redundancy, transmitting all sensory data by individual nodes not only wastes the scarce wireless bandwidth, but also consumes a lot of battery energy. Instead of each source node sending sensory data to its sink for aggregation (the so-called client/server computing), Qi et al. i...

There is evidence that patients with Complex Regional Pain Syndrome (CRPS) have altered central sensorimotor processing. Sensory input can influence motor output either through indirect pathways or through direct connections from the sensory to motor cortex. The purpose of this study was to investigate sensorimotor interaction via direct connections in patients with CRPS and to compare the resu...

This study characterized the spatiotemporal responses in ferret somatosensory cortex after sensory deprivation at different phases of cortical development. We hypothesized that cortical responses to stimulation of intact superficial radial nerve in adults will vary systematically according to maturation of thalamocortical relationships at the time of an ulnar nerve transection. Depending on the...

Bovine herpesvirus 1 (BHV-1) infection induces clinical symptoms in the upper respiratory tract, inhibits immune responses, and can result in life-threatening secondary bacterial infections. Following acute infection, BHV-1 establishes latency in sensory neurons within trigeminal ganglia. Periodically, reactivation from latency occurs, resulting in virus transmission. The latency-related (LR) R...