نتایج جستجو برای: sensory blockade
تعداد نتایج: 133057 فیلتر نتایج به سال:
Objectives: Local anesthetics administered by spinal anesthesia acts through sodium channels. Mutations of channels may be responsible for resistance to local anesthetic agents. The scorpion venom contains neurotoxins that block the In view high prevalence stings in our region and observation failure patients with a history routine practice, present study is planned. Methods: Forty American Soc...
Several lines of evidence have indicated that many nuclei in the brain including preoptic nucleus, AV3V, subfornical organ, septal area and lateral hypothalamus are the targets of efferents from chemo-sensitive and pressure-sensitive systems. These areas may concern with regulation of fluid homeostasis. In the present study, intracerebroventricular injections were carried out in all experiments...
Ketamine (KET) induced blockade of cortical spreading depression (CSD) declines with repeated KET applications in a way suggesting the development of tolerance. Possible mechanism of this process was studied in 31 rats anestheized with pentobarbital. CSD was elicited by injection of 1µl of 5% KCl into cortex at 15 min intervals and monitored by recording the accompanying slow potential waves....
The occurrence of intra-operative conversion disorder with tetraplegia in a patient undergoing emergency appendectomy under spinal anaesthesia has been described this case report. A 19-year-old female was given for an appendectomy. She had block up to the T10 level as per assessment. Following confirmation sensory and motor blockade level, became apnoeic appeared stop responding abruptly. Her v...
Sensory neurons detect chemical stimuli through projections in the skin and mucosa, where several transient receptor potential (TRP) channels act as primary chemosensors. TRP channels are tetramers, and it is generally accepted that binding of ligands causes the opening of a single central cation-conducting pore. Contrary to this view, we here provide evidence for a second permeation pathway in...
Multimodal objects and events activate many sensory cortical areas simultaneously. This is possibly reflected in reciprocal modulations of neuronal activity, even at the level of primary cortical areas. However, the synaptic character of these interareal interactions, and their impact on synaptic and behavioral sensory responses are unclear. Here, we found that activation of auditory cortex by ...
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway
Human genetic studies have revealed an association between GTP cyclohydrolase 1 polymorphisms, which decrease tetrahydrobiopterin (BH4) levels, and reduced pain in patients. We now show that excessive BH4 is produced in mice by both axotomized sensory neurons and macrophages infiltrating damaged nerves and inflamed tissue. Constitutive BH4 overproduction in sensory neurons increases pain sensit...
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