The injection of antigen into the center of the avascular cornea of homologously sensitized animals induced a ring of opacification between the center of the cornea and the limbus. This ring of opacification was composed of a line of deeply eosinophilic amorphous material in a matrix of swollen collagen fibers, palisaded by polymorphonuclear leucocytes. By use of fluor-tagged antigen, it was sh...

Antibody-dependent cell-mediated cytotoxicity (ADCC) against mouse erythrocytes sensitized with immunoglobulin G was studied in mice with malaria. Spleen cells from mice had enhanced cytotoxic activity early in Plasmodium berghei infection but not later in the disease. Sera from infected animals and partially purified malarial immune complexes inhibited ADCC. In addition, ADCC was diminished in...

a sensitive fluorometric method for the determination of deferiprone (dfp) based on the formation of a luminescent complex with tb3+ ions in aqueous solutions is reported. the maximum excitation and emission wavelengths were 295 and 545 nm, respectively. the effects of various factors on the luminescence intensity of the system were investigated and optimized, then under the optimum conditions,...

S ENSITIZATION of animals with allogeneic blood platelets induces accelerated rejection of allogeneic skin as well as renal grafts.2 In the latter instance the histologic lesions of the rejected graft were described as primarily vascular. These as well as earlier observations have suggested that an antigenic relationship exists between blood platelets and vascular endothelium. The experiments t...

Cord factor in the form of emulsion is unable to sensitize mice to react with a more extensive granulomatous response to a subsequent challenge with the same substance. Mice infected with BCG bacilli are sensitized to cord factor. Such animals react to administration of cord factor with a very extensive granulomatous response, much stronger than normal ones. This hypersensitivity seems to be sp...

Rabbits (and human beings) differ widely in the rapidity with which they undergo sensitization with heat killed tubercle bacilli, but after repeated injections all animals become sensitized. Intracutaneous injection of a small quantity of heat killed tubercle bacilli into a previously normal animal produces a nodule which persists from 8 to 12 weeks; the same injection into well sensitized anim...

The interaction of particulate and gaseous pollutants in their effects on the severity of allergic inflammation and airway responsiveness are not well understood. We assessed the effect of exposure to NO(2) in the presence or absence of repetitive treatment with carbon nanoparticle (CNP) during allergen sensitization and challenges in Brown-Norway (BN) rat, in order to assess their interactions...

Cutaneous basophil hypersensitivity, an immune inflammatory reaction characterized by infiltrates of basophils and a delayed time-course, was studied in guinea pigs contact sensitized with oxazolone. Routine histological techniques, employing ordinary paraffin sections, were modified to study this reaction. When biopsies of contact lesions were processed by these methods dense infiltrates of ba...

1. Sensitized guinea pigs injected with normal rabbit or guinea pig serum previous to intravenous inoculation of antigen may be protected against a few lethal doses of antigen. The protection is greater with foreign than with homologous serum and appears to be related roughly to the amount of serum introduced. 2. Sensitized guinea pigs injected with antibody-containing serum preliminary to intr...