Incretin hormones, including glucagon-like peptide-1 (GLP-1), a target for diabetes mellitus (DM) treatment, are associated with cardioprotection. As dipeptidyl-peptidase IV (DPP-IV) inhibition increases plasma GLP-1 levels in vivo, we investigated the cardioprotective effects of the DPP-IV inhibitor vildagliptin in a murine heart failure (HF) model. We induced transverse aortic constriction (T...

In this study, age-dependent changes of sperm quality parameters in Rutilus frisii were investigated. Also, fertilization capacity of breeders was tested using two age groups of males (3 and 4 year old breeders) and one female group (i.e. 4 year old breeders). For fertilization trials, the breeders were crossed randomly among age classes. Between the two age groups, spermatological parameters d...

In order to determine iron and lead content of seminal plasma in water buffalo and to study their associations with the semen characteristics, 54 semen samples were collected from 10 buffalo bulls. The semen characteristics were evaluated; its iron and lead content were estimated by atomic absorption spectrophotometer. The iron and lead content of the seminal plasma (Mean ± SEM) was recorde...

Background: Defective sperm quality is a significant cause of infertility in men. It is known that nitric oxide (NO) is a highly reactive free radical gas which has a dual function, being both a cytotoxic and necessary molecule for normal sperm production. Materials and Methods: To investigate correlation between NO levels with sperm parameters, a case-control study were designed with total of ...

background : methamphetamine (ma) is an illegal amphetamine-like which stimulate the central nervous system. in recent years, ma has been widely abused worldwide. previous studies have suggested that oxidative stress (os) plays an important role in ma-induced toxicity. from this view, antioxidant therapy could be considered as a potential drug therapy in ma abusers. therefore, the objective of ...

BACKGROUND Camelids are induced (reflex) ovulators. We have recently documented the presence of an ovulation-inducing factor (OIF) in the seminal plasma of alpacas and llamas. The objective was to test the hypothesis that OIF exerts its effect via a systemic rather than a local route and that endometrial curettage will enhance the ovulatory response to intrauterine deposition of seminal plasma ...

Introduction Corin is a protease in the natriuretic peptide system. Deleterious CORIN variants are associated with hypertension and heart disease. It remains unclear if to what extent corin deficiency may contribute failure (HF). Methods knockout (KO) mice were used as model. Cardiac function was assessed by echocardiography tissue analysis KO at different ages or subjected transverse aortic co...

Trivariate C macro-elements defined in terms of polynomials of degree 8r + 1 on tetrahedra are analyzed. For r = 1, 2, these spaces reduce to well-known macro-element spaces used in data fitting and in the finite-element method. We determine the dimension of these spaces, and describe stable local minimal determining sets and nodal minimal determining sets. We also show that the spaces approxim...

Fresh and post-thaw parameters (motility, morphology and viability) of stallion epididymal spermatozoa that have been and have not been exposed to seminal plasma were evaluated, and directly compared to fresh and post-thaw parameters of ejaculated spermatozoa. Six sperm categories of each stallion (n=4) were evaluated for motility, morphology and viability. These categories were fresh ejaculate...