mg, it reduces the number of lymphoma stem cells to less than 0.1%, but it reduces the number of normal colony forming hematopoietic cells to between 20 and 30% (5). Any measure which would either increase the killing of lymphoma cells or decrease the killing of normal cells would increase the range of selectivity of the drug. In this paper we report finding such an action with levels of haloth...

Methods This prospective observational study was conducted in open ICU, urban hospital(Hiroshima, Japan) between February 2013 and March 2015. Adult patients intubated within 24 hours from ICU admission and underwent light sedation with dexmedetomidine was eligible. Exclusion criteria were: age < 18, stroke, cardiopulmonary arrest, neurosurgery, seizure, traumatic brain injury. We compared alte...

Strontium (atomic symbol Sr) is a silvery-white alkaline earth metal that exists in several stable (e.g., Sr-86 and Sr-88) and several radioactive (e.g., Sr-89 and Sr-90) isotopic states. Stable strontium and its salts have many industrial uses, such as providing the red color in pyrotechnic devices such as tracer bullets, distress signal rockets, flares, and fireworks. In medicine, strontium b...

A series of 414 chronic pain patients referred to Are Hospital, Are, Sweden, for evaluation and rehabilitation were administered a structured diagnostic interview to detect alcohol and drug misuse and dependence according to DSM-III-R criteria. A total of 97 (23.4%) met criteria for active alcohol, analgesic, or sedative misuse or dependency; an additional 39 (9.4%) met criteria for a remission...

OBJECTIVE To evaluate the effects of early norepinephrine (NE) infusion in children submitted to mechanical ventilation (MV) requiring continuous sedative and analgesic infusion. METHODS Double-blinded, randomized, placebo-controlled trial enrolling children (1 month to 12 years of age) admitted to a Brazilian PICU and expected to require MV and continuous sedative and analgesic drug infusion...

OBJECTIVE To provide a comprehensive review of the issue related to the administration of sedative, analgesic, and neuromuscular blocking agents (NMBA) to patients who are receiving ventilatory support for acute respiratory distress syndrome (ARDS) with high-frequency oscillatory ventilation. RESULTS Sedative, analgesic, and NMBA are used with great frequency in patients with severe ARDS who ...

OBJECTIVE To evaluate associations between exposure to corticosteroids or sedative-hypnotic medications and incident self-reported depressive symptoms in medical inpatients. METHOD The study utilized a prospective cohort design, focusing on acute depressive symptoms developing soon after medication exposure. The incidence of self-reported depressive symptoms was evaluated using a modified ver...

Alcohol tolerance resulting from chronic administration is well known to be accompanied by cross-tolerance to sedative/anesthetic drugs, especially those acting on the gamma-aminobutyric acid type A receptors (GABAARs). Rats treated with chronic intermittent ethanol (CIE) show decreased function and altered pharmacology of GABAARs in hippocampal neurons, consistent with cell- and location-speci...

BACKGROUND Present practice guidelines recommend sedative-analgesic and neuromuscular blocking administration during therapeutic hypothermia in comatose patients after cardiac arrest. However, none suggests the best administration protocol. In this study, we evaluated intensivists' preferences regarding administration. METHODS A systematic literature review was conducted to identify clinical ...