نتایج جستجو برای: secretory treatment

تعداد نتایج: 1419650  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Liping Zhang Zulfeqhar Ali Syed Iris van Dijk Härd Jae-Min Lim Lance Wells Kelly G Ten Hagen

Polarized secretion is crucial in many tissues. The conserved protein modification, O-glycosylation, plays a role in regulating secretion. However, the mechanisms by which this occurs are unknown. Here, we demonstrate that an O-glycosyltransferase functions as a novel regulator of secretion and secretory vesicle formation in vivo by glycosylating the essential Golgi/endoplasmic reticulum protei...

Journal: :Neuron 2010
Qun-Fang Wan Zhen-Yu Zhou Pratima Thakur Alejandro Vila David M. Sherry Roger Janz Ruth Heidelberger

Synaptic vesicle 2 (SV2) proteins, critical for proper nervous system function, are implicated in human epilepsy, yet little is known about their function. We demonstrate, using direct approaches, that loss of the major SV2 isoform in a central nervous system nerve terminal is associated with an elevation in both resting and evoked presynaptic Ca(2+) signals. This increase is essential for the ...

Journal: :BIO web of conferences 2023

Acute intestinal infections (AII) remain one of the most important problems children’s infectious pathology, as this disease is diagnosed with severe forms and mortality remains in high rate. Among patients acute infection, children account for 60-70%. Severe are still noted to lead death young children. In addition, recent years, there has been an increase infections, their clinical manifestat...

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