Two new, sensitive, and selective spectrofluorometric methods were developed for the determination of gemifloxacin mesylate (GFX) in tablets and spiked human plasma. Method A was based on measurement of the enhanced fluorescence spectral behaviour of GFX in a sodium dodecyl sulphate (SDS) micellar system. In aqueous solution of acetate buffer pH 5.5, the fluorescence intensity of GFX was greatl...

Monomer dynamics in sodium dodecyl sulfate (SDS) micellar solution at room temperature as studied by quasielastic neutron scattering (QENS) technique is reported here. The elastic incoherent structure factor (EISF) obtained from the analysis of QENS data suggests that the SDS chain performs uniaxial rotational diffusion along the long molecular axis. The rotation diffusion coefficient is found ...

Glycolipid biosurfactants, such as mannosylerythritol lipids (MELs), are produced by different yeasts belonging to the genus Pseudozyma and have been attracting much attention as new cosmetic ingredients owing to their unique liquid-crystal-forming and moisturizing properties. In this study, the effects of different MEL derivatives on the skin were evaluated in detail using a three-dimensional ...

Hydrophobic ion-pairing (HIP) complexation-based approach has been employed to reduce aqueous solubilities of peptide and protein drugs. The solubility of a protein molecule is due to presence of charged amino acids present on the surface. HIP complexation is a technique to complex ionizable functional groups of protein and peptide molecules with oppositely charged functional groups of a comple...

Yeast and hyphal walls of Candida albicans were extracted with sodium dodecyl sulfate (SDS). Some of the extracted proteins reacted with a specific beta-1,6-glucan antiserum but not with a beta-1,3-glucan antiserum. They lost their beta-1,6-glucan epitope after treatment with ice-cold aqueous hydrofluoric acid, suggesting that beta-1,6-glucan was linked to the protein through a phosphodiester b...

We investigate the nematic-isotropic (N-I) transition in shells of the liquid crystal 5CB, surrounded by aqueous phases that conventionally are considered to be immiscible with 5CB. The aqueous phases contain either sodium dodecyl sulfate (SDS) or polyvinyl alcohol (PVA) as stabiliser, the former additionally promoting homeotropic director alignment. For all shell configurations we find a depre...

The effect of poly(acrylic acid) (PAA), poly(vinylpyrrolidone) (PVP), sodium dodecylsulfate (SDS), hydroxypropylmethylcellulose (HPMC), and D-fructose additives on the growth of BaTiO3 particles by aqueous synthesis is studied. Through different mechanisms, all the tested additives influenced the growth of BaTiO3. For high concentrations, PAA adsorbed on specific crystallographic faces changing...

Solid dispersions (SDs) of ursolic acid (UA) were developed using polyvinylpyrrolidone K30 (PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) or poloxamer 407 (P407) the aim enhancing solubility and vitro release UA. SDs investigated a 24 full factorial design, subsequently selected formulations characterized for water solubilit...

A spectrofluorimetric method to determine the antibiotic moxifloxacin is proposed and was applied to pharmaceuticals, human urine and serum. The fluorimetric method allows the determination of 30-300 ng mL-1 moxifloxacin in aqueous solution containing phosphoric acid-phosphate buffer (pH 8.3) with lambda exc = 287 nm and lambda em = 465 nm. Detection and quantification limits were 10 and 30 ng ...

The aggregation behavior of a novel histidine derivative surfactant N-dodecanoyl-L-histidine (DHis) in aqueous solution was investigated. By mixing with cationic/anionic surfactant, an interesting phase transition over time from transparent homogeneous solution to jelly and finally to fibrous floccules was observed with aggregates growth taken place in the systems. Making use of the growing fib...