Shine-Dalgarno (SD) sequence has been considered as one of the common features of 5' end untranslated region (5'UTR) of prokaryotic transcripts. However, more leaderless bacteria and archaea mRNAs are being increasingly reported in recent years. To understand the distribution of SD-led genes and non-SD-led genes, we have analyzed 162 completed prokaryotic genomes leading to various new conclusi...

assigning facilities to locations is one of the important problems, which significantly is influence in transportation cost reduction. in this study, we solve quadratic assignment problem (qap), using a meta-heuristic algorithm with deterministic tasks and equality in facilities and location number. it should be noted that any facility must be assign to only one location. in this paper, first o...

This paper investigates the performance of several hyperheuristics applied to a real-world personnel scheduling problem. A hyperheuristic is a high-level search method which manages the choice of low level heuristics, making it a robust and easy to implement approach for complex real-world problems. We need only to develop new low level heuristics and objective functions to apply a hyperheurist...

What is the optimal way to make a decision given that your time is limited and your cognitive resources are bounded? To answer this question, we formalized the bounded optimal decision process as the solution to a meta-level Markov decision process whose actions are costly computations. We approximated the optimal solution and evaluated its predictions against human choice behavior in the Mouse...

This paper introduces a novel method for analyzing conceptual design data. Given a database of previous designs, this method identifies relationships between design components within this database. Further, the method transforms these relationships into explicit design knowledge that can be used to generate a ‘heuristic-based’ model of the design domain for use at the conceptual stage. This can...