BACKGROUND The use of hyaluronic acid (HA) for intra-articular (IA) injection is widespread around the world for patients affected by osteoarthritis. AIM The aim of this study is to identify scientific evidence from in vitro and in vivo studies supporting the use of IA HAs marketed in Italy. We also evaluated the accuracy of indications and contraindications reported in the leaflets of such H...

REFERENCES 1. Scientific considerations in demonstrating biosimilarity to a reference product: guidance for industry. US FDA; 2015. 2. Guidelines on evaluation of similar biotherapeutic products (SBPs). WHO; 2009. 3. Guideline on similar biological medicinal products. EMA; 2014. 4. Column proportions test [user guide]. IBM Corporation; 2013. 5. Leading autoimmune patient advocacy group survey f...

Proper scientific investigations on Aloe vera have gained more attention over the last decade due to its reputable, medicinal, pharmaceutical and food properties. Some publications have appeared in reputable scientific journals that have made appreciable contributions to the discovery of the functions and utilizations of Aloe vera lacking processing of leaf gel. Present processing techniques ai...

The launch of Google Scholar Metrics as a tool for assessing scientific journals may be serious competition for Thomson Reuters’ Journal Citation Reports, and for Scopus’ powered Scimago Journal Rank. , A review of these bibliometric journal evaluation products is performed. We compare their main characteristics from different approaches: coverage, indexing policies, search and visualization, b...

The use of digital technologies within research has led to a proliferation of data, many new forms of research output and new modes of presentation and analysis. Many scientific communities are struggling with the challenge of how to manage the terabytes of data and new forms of output, they are producing. They are also under increasing pressure from funding organizations to publish their raw d...

BACKGROUND Recent technological developments in medicine, including modern radiology have promoted the impact of scientific researches on social life. The scientific outputs such as article and patents are products that show the scientists' attempt to access these achievements. OBJECTIVES In the current study, we evaluate the current situation of Iranian scientists in the field of radiology a...

Polar regions are remote and challenging areas on the earth. In view of the unique environment and the severe competition in polar regions, it's considered that the ecological system might be the producer of new compounds with diversity biological activities. This review is an attempt to consolidate the studies about 97 natural products isolated from Antarctic and Arctic organisms including mic...

dna barcoding is a new term introduced in to scientific literatures by hebert and coworkers almost a decade ago. the concept of barcoding alone is well-known to the public: a series of black bars printed on many commercial products (universal product code), which are used to distinguish different products. advances made in molecular biology and molecular techniques late 20th century e.g. sequen...

Computer-based simulations provide new insights at the molecular scale of chemical processes and material properties new products may be developed more economically by a more focused strategy. Thus, the overall product development cycle for new materials and active ingredients can be reduced significantly. R&D explores and evaluates continuously these possibilities and utilizes the enormous pot...

Molecules instituted some years ago a “Best Paper” award to recognize the most outstanding papers in the area of natural products, medicinal chemistry and molecular diversity published each year in Molecules. We are pleased to announce the third “Molecules Best Paper Award” for 2014. The winners were chosen by the Editor-in-Chief and selected editorial board members from among all the papers pu...