In developmental biology, the regulation of stem cell plasticity and differentiation remains an open question. CBP(CREB-binding protein)/p300 is a conserved gene family that functions as transcriptional co-activator plays important roles in wide range cellular processes, including death, DNA damage response, tumorigenesis. The acetyl transferase activity CBPs particularly important, histone non...

Abstract The basal splits within Syndermata probably date back hundreds of millions years, and extant syndermatans greatly differ in reproduction modes (parthenogenesis, metagenesis, heterosexuality) lifestyles (free-living, epizoic, endoparasitic). Against this background, the present investigation aims to reconstruct genome transcriptome metrics last common ancestor (LCA) Syndermata. We espec...

The regulation of scale and proportion in living organisms is an intriguing and enduring problem of biology. Regulatory mechanisms for controlling body size and proportion are clearly illustrated by the regeneration of missing body parts after amputation, in which the newly regenerated tissues ultimately attain a size that is anatomically congruent with the size of the rest of the organism. Und...

All multicellular organisms depend on stem cells for their survival and perpetuation. Their central role in reproductive, embryonic, and post-embryonic processes, combined with their wide phylogenetic distribution in both the plant and animal kingdoms intimates that the emergence of stem cells may have been a prerequisite in the evolution of multicellular organisms. We present an evolutionary p...

Tissue regeneration is a complex process that involves a mosaic of molecules that vary spatially and temporally. Insights into the chemical signaling underlying this process can be achieved with a multiplex and untargeted chemical imaging method such as mass spectrometry imaging (MSI), which can enablede novostudies of nervous system regeneration. A combination of MSI and multivariate statistic...

Chromatin modifications function as critical regulators of gene expression and cellular identity, especially in the regulation maintenance pluripotent state. However, many studies chromatin modification stem cells—and cells particular—are performed mammalian cell culture, an vitro condition mimicking a very transient state during development. Thus, new models for studying vivo could be helpful ...