Sarcoidosis is a multisystem granulomatous disease that can affect any organ in the body, but most commonly the lung. Any part of the thorax may be affected by sarcoidosis, including the lung parenchyma, airways, and mediastinal and hilar lymph nodes. When the parenchyma is involved, sarcoidosis has a predilection for the bronchovascular bundles and subpleural locations. On occasion, the presen...

BACKGROUND Sarcoidosis is a multisystemic disease of unknown etiology characterized by a disproportionate Th1 granulomatous immune response in the organs involved. Plasmatic hypergammaglobulinemia and B cell accumulation in granulomatous lesions suggest the possible role of humoral immune responses in the pathogenesis of sarcoidosis. The purpose of this study is to describe B cell peripheral co...

Sarcoidosis is a multiorgan granulomatous disease in which the skin is one of the frequently involved target organs. Cutaneous involvement occurs in a third of patients with sarcoidosis and has protean manifestations. More than a century has passed since the initial description of sarcoidosis, but its cause continues to be an enigma. Recent studies have introduced several new insights into the ...

sparing in acute sarcoidosis: Results of a double, blind, randomized trial. Sarcoidosis Vasc Diffuse Lung Dis 17:60, 2000 67. Fazzi P: Pharmacotherapeutic management of pulmonary sarcoidosis. Am J Respir Med 2:311, 2003 68. Topalov DT, Videnovic JV, Radosavljenic TR: The long term use of methotrexate in patients with chronic disseminated sarcoidosis. Chest 118:245, 2000 69. Baugmann RP, Lynch J...

INTRODUCTION Sarcoidosis is a systemic granulomatous disease of unknown cause. The management of sarcoidosis remains problematic. Systemic and topical corticosteroids are the mainstay of therapy but may cause unacceptable side effects. Biologic therapies, such as infliximab, have recently been proposed as another treatment option for cutaneous sarcoidosis. CASE REPORT The authors describe thr...

Nodular lung disease is a rare pulmonary manifestation of sarcoidosis and resembles metastatic neoplasm disease. Nodular sarcoidosis is rare, varying from 1.6% to 4% of patients with sarcoidosis. Radiographic nodules measure from 1 to 5 cm in diameter that typically consist of coalescent granulomas. There is limited data on this form of sarcoidosis and its presentation can mimic primary or meta...

Clinical changes of lacrimal gland (LG) in sarcoidosis are studied. 33 patients (66 orbits) with verified systemic sarcoidosis were examined using digital ultrasound. Different varieties of LG structural changes in sarcoidosis are studied. Different types of LG structural changes were determined in patients with sarcoidosis defined as pseudoedematous and combined forms. Analysis of the results ...

Gastrointestinal (GI) sarcoidosis is a very rare disease, which clinically presents along with systemic disease or as an isolated finding. Gastric sarcoidosis is the most common form of GI sarcoidosis. Symptomatic gastric sarcoidosis is rare and only few case reports have been described in the literature with well-documented histological evidence of noncaseating granulomas. We present an intere...

Sarcoidosis is a multisystemic granulomatous disease of unknown aetiology that usually presents with bilateral hiliar adenopathies, pulmonary infiltrations, and ocular and cutaneous lesions. The specific cutaneous lesions, or granulomatous, are produced in from 9% to 37% of patients with systemic sarcoidosis. Nevertheless, few patients have been described having specific lesions from sarcoidosi...

Because of its wide availability, echocardiography is the most frequently used modality for diagnosis of the underlying substrate for cardiac arrhythmia. However, echocardiography is unable to visualize intramyocardial substrates for reentrant arrhythmia such as fat or scar fibrosis. Replacement of myocytes with nonviable tissue results in hypertrophy of the remaining viable cells and is associ...