Patients with SCAD and concomitant COPD are at high risk of cardiovascular adverse events, due to chronic inflammation, responsible of endothelial dysfunction, oxidative stress and heightened platelet reactivity (PR). The objective of this randomised clinical trial was to test if ticagrelor is superior to clopidogrel in improving endothelial function in patients with stable coronary artery dise...

OBJECTIVE To assess the prevalence, clinical presentation, therapeutic management and medium-term prognosis of spontaneous coronary artery dissection (SCAD). METHODS Over a 5-year period, and out of a cath-lab database of 11,605 files, 23 cases of SCAD were confirmed by re-analysis of angiograms. Therapeutic management and in-hospital outcome were obtained from medical files and prospective f...

SPONTANEOUS CORONARY ARTERY DISSECTION (SCAD) REPRESENTS A DIAGNOSTIC CHALLENGE (1,2). In this study, we used a combined imaging strategy, intravascular ultrasound (IVUS) and optical coherence tomography (OCT), in 8 patients with SCAD. The diagnosis of SCAD required the visualization of an intimomedial membrane with a double-lumen or intramural hematoma (Figs. 1, 2, and 3). Their mean age was 5...

Ethylmalonic encephalopathy is a devastating, infantile, autosomal recessive, metabolic disorder caused by defects in the mitochondrial sulfur dioxygenase, ETHE1, and characterized by ethylmalonic and methylsuccinic aciduria, lactic acidemia associated with developmental delay, orthostatic acrocyanosis, recurrent petechiae, chronic diarrhea, and abnormalities on brain MRI. The authors also repo...

Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome occurring predominantly in young women without any cardiovascular risk factors, especially during the peripartum and early postpartum period. Here, we report a case of a 28-year-old pregnant woman who was found to have an isolated distal SCAD of the left anterior descending artery (LAD). Coronary angiograph...

A 49-year-old man complained of sudden upper abdominal pain but was not given a definitive diagnosis. The day after he was discharged, he noticed left chest pain. An in-depth electrocardiogram indicated acute myocardial infarction, and emergent coronary angiography revealed 99% stenosis of his left coronary artery. An intravascular ultrasound revealed spontaneous coronary artery dissection (SCA...

The authors searched for the presence of alpha-1-antitrypsin (AAT) deficiency alleles PiZ and PiS in 74 patients with spontaneous cervical artery dissections (sCADs) and in 74 healthy control subjects. In both groups, the authors found four carriers of deficiency alleles. The connective tissue morphology of one additional patient with sCAD with PiZM genotype and her relatives was studied in ski...

We read with great interest the elegant study by Saw et al. (1) that carefully described predisposing conditions in a large Canadian series of 50 patients with spontaneous coronary artery dissection (SCAD). Notably, fibromuscular dysplasia (FMD) in noncoronary territories was found in 86% of patients. Due to the exhaustive screening for associated conditions and the potential clinical implicati...

Abstract Background Spontaneous coronary artery dissection (SCAD) is a common and under-recognized cause of myocardial infarction during the post-partum period. Case Summary We report case young women presenting with chest pain in Her clinical appearance was that angiography indicative Type 2 spontaneous (SCAD). The patients had persistent pain, reduced left ventricular function critical anteri...