OBJECTIVE Type 2 diabetes is a complex disease that is accompanied by elevated levels of nonesterified fatty acids (NEFAs), which contribute to β-cell dysfunction and β-cell loss, referred to as lipotoxicity. Experimental evidence suggests that oxidative stress is involved in lipotoxicity. In this study, we analyzed the molecular mechanisms of reactive oxygen species-mediated lipotoxicity in in...

High water-cut oil production is one of the major issues in petroleum industry. The present study investigates different profile control solutions, with an emphasis on selective methods and materials that mostly decrease permeability water-saturated reservoir areas. To achieve water flow blockage fractured porous media, sodium silicate-based gel-forming composition was developed. test procedure...

The comparative biological activity of 21 naturally occurring or synthetically derived steroids, 7 tetracyclic and pentacylic triterpenoids, and antheridiol incubated with cultures of Phytophthora cactorum has been examined. There was greater dependence on precise steric features of the sterol side chain than on the extent of nuclear unsaturation in inducing oospore formation. There was no sign...

The formation of an atypical, saturated, diarylated, Heck/Suzuki, domino product produced under oxidative Heck reaction conditions, employing arylboronic acids and a chelating vinyl ether, has been investigated by DFT calculations. The calculations highlight the crucial role of 1,4-benzoquinone (BQ) in the reaction. In addition to its role as an oxidant of palladium, which is necessary to compl...

The role of n-6 polyunsaturated fats upon the formation of the mutagenic DNA adduct malondialdehydedeoxyguanosine (M1dG) in blood was investigated in male volunteers (n = 13) who consumed diets high in saturated and polyunsaturated fats, and polyunsaturated fat plus a-tocopherol supplemention (400 IU per day). On day 14 there was a significant difference in adduct levels between diets with satu...

1. Experimental details All reagents were purchased from Aldrich, the commercial ThT(Cl) was recrystallized in acetonitrile. The slow addition of an aqueous saturated solution of KI (5 ml) to an aqueous solution (20 ml) of (ThT)Cl (0.600 g, 1.88 mmol) resulted in the formation of a yellow solid that was filtered off, washed with cold water (10 ml) and dried in vacuo. MS(+ESI-MS) showed the pres...

Introduction: Recently published reports on chemical and physical properties of Mars sediments indicate that diagenetically altered volcanic rocks were reworked by sedimentary processes [1]. Furthermore, compositional and petrographic aspects of sediments show varying degrees of elemental enrichment as well as complex interaction between the minerals in partially saturated or saturated conditio...

The phosphatidate-synthesizing system of rat-liver microsomes was resolved into two component enzymes, glycerolphosphate acyltransferase and 1-acylglycerolphosphate acyltransferase. The resolution is effected by sucrose density gradient centrifugation in the presence of a nonionic detergent, Triton X-100. Combination of both enzymes results in reconstitution of the phosphatidate-synthesizing sy...

abstract the temperature of water entering the soil or variation in soil temperature has a direct impact on soil hydraulic conductivity via the effect on water viscosity. in this research, the time variability of soil saturated hydraulic conductivity (ks) was studied. the relation between soil temperature and fluid viscosity with hydraulic conductivity were also studied. the necessary experimen...