486 | Med. Chem. Commun., 2015, 6, 486–491 This journal is © The R Department of Biochemistry, Yong Loo Lin School of Medicine, and Synthetic Biology Research Program, Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore 117456. E-mail: [email protected] † Electronic supplementary information (ESI) available. See DOI: 10.1039/ c4md00537f ‡ Author contribution: ...

By a frame-shift mutation, we have engineered a human IGF-I receptor (IGF-IR) cDNA that produces a receptor 486 amino acids long (plus the 30 amino acids of the signal peptide). This receptor, which we have designated as 486/STOP, is partially secreted into the medium of cells in culture and markedly inhibits the autophosphorylation of the endogenous IGF-IRs as well as the activation of the sig...

Ph.D Scholar, Department of Orthopaedics, King George’s. Medical University, Lucknow, India 2 Professor, Department of Orthopaedics, King George’s. Medical University, Lucknow, India Associate Professor, Department of Medicine, King George’s. Medical University, Lucknow, India 4 Associate Professor, Department of Radiology, King George’s. Medical University, Lucknow, India 5 Professor & Head, D...

a Child Protection Team, King Saud University Medical City, Riyadh, Saudi Arabia b Department of Emergency Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia c Department of Pediatrics, King Saud University Medical City, Riyadh, Saudi Arabia d Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia e Psychiatry Department, King Saud University Medical City, Riyadh, Saudi Ar...

due to its geopolitical position, the city of antioch had always been the scene of confrontation and tension between the great powers of the ancient era since its establishment in the seleucid era until the late sassanid era. the findings of this research indicate that the structure of antioch was checkered in pattern and it derived its political, economic, commercial, religious and military si...

in this study, postharvest characteristics of eight cut rose cultivars (valentine, king pride, prima donna, black baccara, victory, papagayo, royal baccara and yellow island) were investigated in a growth room with temperature of 20 ºc, relative humidity of 50% and light intensity of 10 µmol m-2 s-1 in autumn 2008. among cultivars significant differences were found for all of the attributes eva...

in its course of evolution, the sassanian rule accepted a change in temporal exigencies, condition and manner of governance of each ruler where more attention was paid to the institutional establishment, grades/ranking, titles, symbols and administrative hierarchy. in a way, the organizational manner, to a larger extent, could engulf the period into a curtain of ambiguity. one of those ranks wa...