A Síndrome da Apneia Obstrutiva do Sono (SAOS) caracteriza-se pela obstrução parcial ou completa via aérea superior, de forma intermitente e recorrente. Decorre colapsos região faríngea, propiciando redução substancial fluxo aéreo, determinando apneia hipopneia. Está associada a diversos sintomas comorbidades, como sonolência excessiva diurna, déficit cognitivo, depressão, obesidade, qualidade ...

BACKGROUND TRPV6 ion channels are key mediators of regulated transepithelial absorption of Ca2+ within the small intestine. Trpv6-/- mice were reported to have lower bone density than wild-type littermates and significant disturbances in calcium homeostasis that suggested a role for TRPV6 in osteoblasts during bone formation and mineralization. TRPV6 and molecules related to transepithelial Ca2...

The purpose of the present work was to examine the effect of different Ti-6Al-4V surface treatments on osteoblasts behaviour. Previous work in this laboratory has demonstrated that an ageing treatment reduces metal ion release from this alloy compared to standard passivation procedures. In this study. human osteosarcoma MG-63 were used in short-term in vitro tests to assay for cell viability an...

The purpose of these studies was to determine the effect of adenovirus-mediated interleukin-12 (IL-12) gene transfer on the growth and development of osteosarcoma (OS) lung metastases in nude mice. A nude mouse model was produced by repetitive cycling of human SAOS OS cells through the lung. The resultant SAOS-LM6 cell line produced microscopic lung metastases by 5-6 weeks after i.v. injection ...