Artificially regulating gene expression is an important step in developing new treatment for system-level disease such as cancer. In this paper, we propose a method to regulate gene expression based on sampled-data measurements of gene products concentrations. Inherent noisy behaviour of Gene regulatory networks are modeled with stochastic nonlinear differential equation. To synthesize feed...

Based on the synchronous language elements introduced in Modelica 3.3, a library is described to utilize the new features in a convenient way for graphical model definition of sampled data systems. The library has elements to define periodic clocks and event clocks that trigger elements to sample, subsample or super-sample partitions synchronously. Optionally, quantization effects, computationa...