OBJECTIVES The biphasic kill curve of isoniazid against Mycobacterium tuberculosis in guinea pigs is due to the presence of persisters rather than selection of isoniazid-resistant mutants. To determine whether this phenomenon is common to other bactericidal drugs, we studied the activity of streptomycin and its ability to select for streptomycin-resistant mutants in the guinea pig model of tube...

Three mutant strains of Arabidopsis thaliana var Columbia were selected for their ability to germinate in elevated concentrations of NaCI. They were not more tolerant than wild type at subsequent development stages. Wild-type strains could not germinate at concentrations >125 mM NaCI. l w o of the mutant strains, RS17 and RS20, could withstand up to 225 mM, whereas RS19 was resistant to 175 mM....

Cytotoxic brain edema—swelling of nerve and glial cells—is among the very early pathophysiologic sequelae of focal cerebral ischemia. Once cell swelling has exhausted the cerebral compliance, intracranial pressure increases and, thereby, causes secondary ischemia. Hypertonic solutions, mannitol in particular, have long been used to reduce intracranial pressure. More recently, hypertonic saline ...

Multidrug-resistant breast cancers have limited and ineffective clinical treatment options. This study aimed to develop PLGA nanoparticles containing a synergistic combination of vincristine and verapamil to achieve less toxicity and enhanced efficacy on multidrug-resistant breast cancers. The 1:250 molar ratio of VCR/VRP showed strong synergism with the reversal index of approximately 130 in t...

BACKGROUND Radiofrequency catheter ablation of accessory pathways (APs) is very effective in all but a minority of patients. We examined the usefulness and safety of irrigated-tip catheters in treating patients with APs resistant to conventional catheter ablation. METHODS AND RESULTS Among 314 APs in 301 consecutive patients, conventional ablation failed to eliminate AP conduction in 18 APs i...

The emergence of antibiotic-resistant Salmonella is of concern to food processors. The objective of this research was to identify antimicrobial activities of cinnamaldehyde and carvacrol against antibiotic-resistant Salmonella enterica in phosphate-buffered saline (PBS) and on celery and oysters. Twenty-three isolates were screened for resistance to seven antibiotics. Two resistant and two susc...

A feared complication of ventricular access for drainage or shunting is ventriculitis. Early diagnosis and treatment is vital to prevent morbidity and mortality. Efficacy of directed antibiotic therapy in ventriculitis is limited by increasing multidrug resistant microorganisms and insufficient systemic antibiotic absorption into the cerebrospinal fluid. Treatment may involve intravenous and/or...

conclusions the result of the current study showed the growing number of nosocomial infections associated with xdr a. baumannii causing difficulties in antibiotic therapy. resistant strains increasingly cause public health problems; therefore, their early detection is essential for healthcare centers. results among the 121 isolated a. baumannii, 44% and 56% were isolated from female and male, r...

Two patients undergoing endocavitary ablation for resistant supraventricular tachycardia had cross sectional echocardiography performed during the ablative procedure. In both cases immediate opacification of the right heart cavities occurred at the time of the current discharge. The contrast effect was similar to that resulting from a peripheral venous injection of dextrose or saline during ech...

A dose of approximately 8,400 RAD noticeably lowered the number of viable cysts of E. histolytica in a clear, saline suspension, as calculated by the Most Probable Number method. Doses of approximately 16,700 RAD and more destroyed more than 99% of viable cysts. The relation between increasing cyst mortality and increasing gamma-ray dosage is represented by a logarithmic straight line. A differ...