In serum there are two classes of hexosaminidase. One of these is heat-labile and is inactive in children with Tay-Sachs disease. Serum from heterozygotes for Tay-Sachs disease has half the normal activity of the heat-labile enzyme. The heat-labile enzyme can be inactivated by heating serum diluted in buffer for 5 mm at 60 #{176}C. We have used this property to develop a reliable, fully automat...

Mr. Sachs has served on the Hospital Board as chairman of the building committee, vice-president, and a member of the executive committee. A graduate of Washington University, Mr. Sachs has been active in the promotion and advancement of the electrical industry since 1924. His company has participated in most of the major electrical developments in the St. Louis area and is known throughout the...

Skin punch biopsies of six children suffering from infantile or late onset Tay-Sachs disease, juvenile Sandhoff disease, or GM gangliosidosis type I, contained axons which, when viewed with the electron microscope, were distended by large amorphous black deposits. These are nonspecific residual bodies. Their large numbers indicate severe disturbance of the nerve cell and may be part of the dyin...

Majorana’s arbitrary spin theory is considered in a hyperbolic complex representation. The underlying differential equation is embedded into the gauge field theories of Sachs and Carmeli. In particular, the approach of Sachs can serve as a unified theory of general relativity and electroweak interactions. The method is extended to conformal space with the intention to introduce the strong inter...

Partial resurfacing of the humeral head with the Hemicap implant has recently become available. Previously, the use of resurfacing in the glenohumeral joint has been used for the treatment of osteoarthritis, cuff tear arthropathy, rheumatoid arthritis, and avascular necrosis. The technique has provided significant pain relief as well as improved function in all pathologies in the available shor...

In this work it is shown that there are some spatially homogeneous but anisotropic models (Kantowski-Sachs and Bianchi type-III), with a positive cosmological constant, for which the inhomogeneities in the distribution of matter on the surface of the last scattering produce anisotropies (in large angular scales θ ∼ > 10 ◦) that do not differ from the ones produced in Friedmann-Lemâıtre-Robertso...

story. Poor countries are poor, in their view, because the poor do not behave like "us". The battle against poverty thus becomes a battle against corruption, wrong ideas and incompetence, and little more. Of course, the morality tale sometimes fits, as in present-day Zimbabwe, where an ageing tyrant, surrounded by rapacious lieutenants, is destroying his country in a vain and desperate attempt ...