BACKGROUND Failed shoulder instability surgery is mostly considered to be the recurrence of shoulder dislocation but subluxation, painful or non-reliable shoulder are also reasons for patient dissatisfaction and should be considered in the notion. METHODS The authors performed a revision of the literature and online contents on evaluation and management of failed shoulder instability surgery....

In a previous letter to the editor, Sachs and Lecar (1991) described a model for gating of mechanosensitive ion channels. This treatment draws on our "gating-spring" model for gating, which involves an elastic element that conveys force to the channel (Corey and Hudspeth, 1983; Howard and Hudspeth, 1988) and extends it to deal with the elasticity of the channel protein itself. The gating-spring...

Tay-Sachs disease (GM2 gangliosidosis, type 1; TSD) is an autosomal recessive GM2 gangliosidosis resulting from the deficient activity of the lysosomal hydrolase beta-hexosaminidase A (Hex A). With a carrier frequency estimated at 1 in 25, it is a common lysosomal disorder in the Ashkenazi Jewish population. Tay-Sachs disease has provided the prototype for the prevention of severe recessive gen...

BACKGROUND By late 1993, the genes for cystic fibrosis and Gaucher disease and the mutations common among Ashkenazi Jews had been identified. In response to these advances, heterozygote screening for cystic fibrosis and Gaucher disease was added to the more than 20-year-old Tay-Sachs disease screening program at New York University Medical Center, New York, NY. OBJECTIVE To review the outcome...

Jeffrey D Sachs tells Fiona Fleck why investing in renewable energy is good for our health, but why poor countries need more time to make the switch.

A sociedade civil demanda cada vez mais a responsabilidade socioambiental dos entes públicos. Neste contexto, este artigo apresenta um estudo de caso realizado no município Maricá-RJ ao qual aborda social na gestão pública. pesquisa teve como objetivo analisar as ações do poder público cidade Maricá e discutir elas estão correlacionadas com cinco dimensões ecodesenvolvimento propostas por Sachs...