Cocrystallization of drug with coformers is a promising approach to alter the solid state properties substances like solubility and dissolution. The objective present work was preparation, formulation evaluation clozapine cocrystal by screening various coformers. Clozapine co-crystals were prepared using different benzoic acid, fumaric sodium saccharin acetate. Cocrystals solvent evaporation me...

Most known applications of saccharin and saccharyl derivatives and their potential for new uses rely on the thermal and photochemical stability of the saccharyl system. Here, we show that saccharin undergoes structural rearrangement when subjected to a narrow-band ultraviolet irradiation. Monomeric saccharin was isolated in low-temperature argon matrices and its photochemistry was characterized...

The presence of hydrophobic sites in the lectin-I molecule was indicated by hydrophobic probes like 1-anilinonapthalene-8-sulfonic acid (ANS), 2-p-toluidinyl napthalene-6-sulfonic acid (TNS). N-phenyl-1-napthylamine (NA) and rose bengal (RB). This was further confirmed by amino acid modifications in the hydrophobic region of the lectin-I molecule. The binding of ANS, TNS, NA and RB to lectin-I ...

Here, we investigated the physicochemical and storage characteristics of Tteokgalbi using n-3 fatty acid-enriched pork (n-6/n-3 ratio: 3.220) explored effects treatment with watermelon radish powder (W; 0–4%). groups were prepared 0% W (control (CON)), 1% (W1), 2% (W2), 4% (W3), or 0.05% ascorbic acid as a reference (REF) treatment. addition to increased moisture ash contents water-holding capa...

The title mononuclear complex, [Zn(C(8)H(11)N(2)O(3)S)(2)], is a zinc salt of 2-(2-pyridylmethyl-amino)ethane-sulfonic acid (Hpmt). The Zn(II) ion is located on an inversion centre and is octahedrally surrounded by four N and two O atoms. The deprotonated pmt(-) anion coordinates in a facial arrangement through its two N atoms and one of the sulfonate O atoms. The crystal packing is determined ...

A high-density sulfonic acid polymer, grafted onto a carrier surface, was synthesized from the acid form of vinylsulfonic acid monomer, and its catalytic activity as a new class of heterogeneous acid catalyst demonstrated in esterification reactions.

the microphase separation of hydrated perfluorinated sulfonic acid membrane nafion was investigated using dissipative particle dynamics (dpd). the nafion as a polymer was modelled by connecting coarse grained beads which corresponds to the hydrophobic backbone of polytetrafluoroethylene and perfluorinated side chains terminated by hydrophilic end particles of sulfonic acid groups [1, 2]. each f...

A fully hydrated Nafion membrane is generally treated as a three-component system comprising the tetrafluoroethylene-like main chain, fluorinated side chain ending with sulfonic acid group, a...

Hindbrain administration of MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) channel blocker, increases meal size, suggesting NMDA receptors in this location participate in control of food intake. However, dizocilpine (MK-801) reportedly antagonizes some non-NMDA ion channels. Therefore, to further assess hindbrain NMDA receptor participation in food intake control, we measured deprivation-...