نتایج جستجو برای: s100
تعداد نتایج: 3609 فیلتر نتایج به سال:
Design Formalin-fixed, paraffin-embedded tissue microarrays (TMAs) consisting of malignant and metastatic melanoma, including SCM and DM (n = 72), were stained by immunohistochemistry and compared in a direct study using a mouse monoclonal SOX10 [BC34] (nuclear), a Pan Melanoma antibody cocktail (cytoplasmic) (Biocare Medical) and a polyclonal S100 antibody (cytoplasmic/ nuclear) (Dako). TMA ti...
abstract deep seated cavernous angioma (ca) is a very rare entity, those occurring in the hypothalamus are still less common. we present a case of a 52-year-old man who presented with behavior and memory disturbance attacks. he had a ca of the hypothalamus as revealed by magnetic resonance imaging (mri). we will discuss the role and importance of imaging in such scenario and also the differenti...
neurofibroma is an autosomal dominant disorder which has major criteria such as hyperpigmentation (cafe-au lait spots), cutaneous and subcutaneous tumors and bone deformities. in this report, a case of multifocal intraosseous neurofibroma in a 16-year-old male with right facial asymmetry, multiple unerupted maxillary posterior teeth and a previous history of infratemporal and orbital neurofibro...
The authors evaluated neuron-specific enolase (NSE), S100 calcium-binding protein B (S100B), and heat shock protein 70 (HSP 70) levels and their relationships with in-hospital mortality, Glasgow Coma Scale (GCS) scores, and National Institute of Health Stroke Scale (NIHSS) scores. In total, 35 patients older than 18 years were presented to our emergency department and were diagnosed with non-tr...
Up to now, the 'hardwired' neural pathway of the neuro-immune regulation is not fully understood. Here we reported a new neural pathway which links sympathetic nerves with immune cells of the lymphoid tissues. Our results demonstrated that nerve fibers derived from superior cervical ganglion directly targeted only S100(+) cells in the cervical lymph nodes. Moreover, we found co-expression of ne...
کولیت اولسراتیو، کرون، سندرم روده تحریک پذیر و کارسینومای کولون از جمله بیماری های مزمن کولون می باشند علائم و عوارض این بیماری ها تا پایان عمر همراه بیمار است و کیفیت زندگی بیمار را تا حد زیادی کاهش می دهند. بهترین و موثرترین راه درمانی برای این بیماری ها، درمان از طریق دارورسانی موضعی می باشد اینجاست که بحث دارورسانی به کولون مطرح می شود. سامانه های کولونی بخاطر داشتن مزایایی چون: اثر درمانی ...
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease which commonly shows a remitting-relapsing course. Monitoring disease activity and adaptation of immune-suppressive therapy is still a challenge in clinical practice. In previous work our group has shown that members of the S100-protein family are reliable biomarkers for monitoring arthritis in JIA patients on medication and ...
Annexin A2 (AnxA2) was originally identified as a substrate of the pp60v-src oncoprotein in transformed chicken embryonic fibroblasts. It is an abundant protein that associates with biological membranes as well as the actin cytoskeleton, and has been implicated in intracellular vesicle fusion, the organization of membrane domains, lipid rafts and membrane-cytoskeleton contacts. In addition to a...
The fused-type S100 protein profilaggrin and its proteolytic products including filaggrin are important in the formation of a normal epidermal barrier; however, the specific function of the S100 calcium-binding domain in profilaggrin biology is poorly understood. To explore its molecular function, we determined a 2.2 Å-resolution crystal structure of the N-terminal fused-type S100 domain of hum...
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