نتایج جستجو برای: s thrombasthenia
تعداد نتایج: 711432 فیلتر نتایج به سال:
Background: The most common polymorphisms identified in the Methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C lead to defective activity of this enzyme and increase the risk of venous and arterial thrombosis. There are limited investigations regarding the effects of thrombogenic polymorphisms on the clinical phenotypes of rare hereditary hemorrhagic disorders like Glanzmann's t...
The molecular nature of platelet receptors for quinineand quinidine-dependent antiplatelet antibodies (Q.Ab and Qd.Ab) was studied by immunoblotting. One Q.Ab caused quinine-dependent lgG binding to platelet proteins with molecular weights (mol wts) of 1 74 Kd and 93 Kd and another to only a 93-Kd protein. A third Q.Ab caused binding to 1 74-. 140-. 93-. and 57-Kd proteins, while a fourth Q.Ab ...
Platelets play a critical role in hemostasis and are involved in wound repair and inflammatory processes. Contact to the subendothelial matrix induces platelet activation that is followed by release of cytokines and growth factors and formation of a vascular plug. Several inherited defects of platelet function resulting in bleeding diathesis are known. However, only in the minority of these dis...
Patients with Glanzmann thrombasthenia (GT) may form isoantibodies which induce refractoriness or inhibition of function of transfused platelets. We monitored the survival and function of transfused platelets by flow cytometry and thrombelastography in a patient with GT. Gating on CD42a+ allowed identification of even a few transfused platelets. Only by gating on these CD41+ CD42a+ cells were w...
The procoagulant activity of platelets induced by collagen, thrombin, and collagen plus thrombin, measured as their capacity to promote the conversion of prothrombin to thrombin in the presence of factors Va and Xa, was studied in patients with alpha, alpha delta, and delta storage pool deficiency (SPD), thrombasthenia, and in two new patients with isolated defects in platelet coagulant activit...
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