objective(s) inhibitors of p38 map kinase are considered as suitable target in the treatment of inflammatory diseases such as rheumatoid arthritis and bowel inflammatory diseases. the development of 5-alkylthio-1-aryl-2-(4-pyridinyl) triazoles as inhibitors of p38 map kinase is described. these are analogues of 4- pyridinyl imidazole p38 map kinase inhibitor reported by merck research laborator...

BACKGROUND AND PURPOSE The cause of "posterior reversible encephalopathy syndrome" (PRES) is not established. We recently encountered several patients who developed PRES in the setting of severe infection. In this study, we comprehensively reviewed the clinical and imaging features in a large cohort of patients who developed PRES, with particular attention to those with isolated infection, seps...

For a map S : X → X and an open connected set (= a hole) H ⊂ X we define JH(S) to be the set of points in X whose S-orbit avoids H. We say that a hole H0 is supercritical if (i) for any hole H such that H0 ⊂ H the set JH(S) is either empty or contains only fixed points of S; (ii) for any hole H such that H ⊂ H0 the Hausdorff dimension of JH(S) is positive. The purpose of this note is to complet...

In our earlier paper [A square root map on Sturmian words, Electron. J. Combin. 24.1 (2017)], we introduced a symbolic square root map. Every optimal squareful infinite word s contains exactly six minimal squares and can be written as a product of these squares: s = X2 1X 2 2 · · · . The square root √ s of s is the infinite word X1X2 · · · obtained by deleting half of each square. We proved tha...

We give digital analogues of classical theorems of topology for continuous functions defined on spheres, for digital simple closed curves. In particular, we show the following: 1) A digital simple closed curve S of more than 4 points is not contractible, i.e., its identity map is not nullhomotopic in S ; 2) Let X and Y be digital simple closed curves, each symmetric with respect to the origin, ...

Let $\tilde{f}\colon(S^2,\widetilde{A})\circlearrowleft$ be a Thurston map and let $M(\tilde{f})$ its mapping class biset: isotopy classes rel $\widetilde{A}$ of maps obtained by pre- post-composing $\tilde{f}$ the group $(S^2,\widetilde{A})$. $A\subseteq\widetilde{A}$ an $\tilde{f}$-invariant subset, $f\colon(S^2,A)\circlearrowleft$ induced map. We give analogue Birman short exact sequence: ju...

We study the minimal complex surfaces of general type with pg = 0 and K 2 = 7 or 8 whose bicanonical map is not birational. We show that if S is such a surface, then the bicanonical map has degree 2 (see [MP1]) and there is a fibration f : S → P such that: i) the general fibre F of f is a genus 3 hyperelliptic curve; ii) the involution induced by the bicanonical map of S restricts to the hypere...

We study bifurcations of a three-dimensional diffeomorphism, g 0 , that has a quadratic homoclinic tangency to a saddle-focus fixed point with multipliers (λe iϕ , λe −iϕ , γ), where 0 < λ < 1 < |γ| and |λ 2 γ| = 1. We show that in a three-parameter family, g ε , of dif-feomorphisms close to g 0 , there exist infinitely many open regions near ε = 0 where the corresponding normal form of the fir...