1,3-dialkyl 3-phenylpyrrolidine-2, 5-diones were modified to produce potential steroid sulphatase inhibitors. these modifications were aimed at producing compounds, which could be expected to bind reasonably well to the active site of the steroid sulphatase enzyme but could not be hydrolyzed readily by the enzyme due to the covalent s-c bond present. in this regard the sulphinic acid derivative...

treatment of bone metastases comprises over 10% of the workload of a radiation-oncology center. bone metastases produce severe pain and immobility, necessitate narcotic use, and reduce the quality of life. a good palliative treatment must be complete, free from side effects and fast; thus we decided to evaluate strontium-89 (89sr) effectivity for palliation of breast and prostate cancer bone me...

objective(s): this study focused on determining cytotoxic effects of copper oxide nanoparticles (cuo nps) on chronic myeloid leukemia (cml) k562 cell line in a cell-specific manner and its possible mechanism of cell death. we investigated the cytotoxicity of cuo nps against k562 cell line (cancerous cell) and peripheral blood mononuclear cell (normal cell). materials and methods: the toxicity w...

abiotic stress are the main factors causing low growth and yield in crops. osmotic stress is an important stress and in case of salinity stress is presuming at the first step. there are different experimental and computational methods to study plant response to stress and lead to better understanding of mechanism involved in these conditions and improvement of plant tolerance to stress. upstrea...

lamno3 and lamno3/zsm-5 nano catalysts were synthesized by pechini method and their physical-chemical properties were characterized using xrd, ftir, sem-edx, uv-vis drs, bet surface area and tpr. the correlation between characteristic properties and activity of catalysts were investigated. the catalytic performance of the catalysts was evaluated in combustion of 2-propanol and compared with 1% ...

background: activation of inflammatory cells can cause more chemicals induced-hepatotoxicity. aflatoxin b1 (afb1) is a fungal toxin that induces acute hepatotoxicity in humans and animals. this study was conducted to examine the effect of co-exposure lps and various aflatoxin b1 doses on the damage hepatic parameters in isolated perfused rat liver. methods: thirty-two male wistar rats (250-300g...

to study the response of pinto-bean yield and yield components in intercropping with maize and naked-pumpkin under weed competition, two similar experiments were conducted in rasht and roudsar separately each in a randomized complete block design with 3 replications on factorial arrangements experiment in 2013. the treatments of first factor consisted of  pinto bean (100 and 75%) sole cropping,...

the purpose of the current study was to evaluate the anti-inflammatory activity of tetramethlpyrazine on oxazolone-induced colitis mice. spleen mononuclear cells (smc), lamina propria mononuclear cells (lpmc) and peripheral blood mononuclear cells (pbmc) were isolated from oxazolone-induced colitis and normal mice. the colitis cells treated by oxazolone were randomly divided into model, low dos...