in this paper, a hybrid method for limited resource allocation and leveling in complex multi-stage, multi-product and multi-period production planning problems with aim of lot-size determination and total cost minimization has been proposed. this problem consists of multiple products with sequential production processes that are produced in different periods to meet the customers demand. by det...

in this paper, we present a genetic algorithm (ga) for optimization of a multi-mode resource constrained time cost trade off (mrctct) problem. the proposed ga, each activity has several operational modes and each mode identifies a possible executive time and cost of the activity. beyond earlier studies on time-cost trade-off problem, in mrctct problem, resource requirements of each execution mo...

We reported earlier that the methylation of unmethylated reovirus mRNA (reo mRNAU) by the cellular methylating enzymes is impaired in extracts of uninfected, interferon-treated Ehrilich ascites tumor cells (S30INT). We find now that after the methylation of reo mRNAU has stopped in S30INT, the RNA can be reisolated and further methylated in an extract of control cells (S30C). Thus the impairmen...

brassinosteroids are phytohormones possessing a wide spectrum of antistress activity. to seewhether this hormone is able to ameliorate the effects of water stress, the effects of 24-epibrassinolise onplant growth, accumulation of osmolytes (proline, sugars and ions), lipid peroxidation and electrolyte leakagewere investigated in colza (brassica napus l. cv. fusia) plants which were under water ...

The Formation of Environmental Literacy Based on a Multidimensional and Multimedia Curricular Perspective B. Poorma’soom I. Fayyaaz, Ph.D. S. Baazargaan, Ph.D. In today’s world the concept of literacy includes not only the basic knowledge and values of the environment, but and skills of protecting it. Environmental education, however, like any other area, requires ea...

cladribine, an analogue of deoxyadenosine, is highly toxic for both non-dividing and proliferating cells and has shown activity in the treatment of several malignancies. therefore, the aim of the present study is to investigate the cytotoxicity effect of cladribine (2-cda) on the breast cancer cell line, mcf-7 (estrogen receptor positive, er+). mtt assay, annexin v-fluorescein/pi and hoechst 33...

Affected by globalization and increased complexity, supply chain managers have learned about the importance of Sales and Operations Planning (S&OP). However, in large scale supply chains, S&OP has received little attention, by both academics and practitioners. The purpose of this manuscript is to investigate the advantages of S&OP process using a mathematical modeling approach in a large scale ...