Trust and confidence have been identified as crucial for efforts at solving the conundrum of high-level radioactive waste management (RWM). However, mistrust has its virtues, especially in form “civic vigilance”—healthy suspicion towards powers that be. This article examines civic vigilance “watchdog journalism,” practiced by leading Finnish French newspapers—Helsingin Sanomat (HS) Le Monde (LM...

Local, rather than systemic, drug delivery to the inner ear is becoming more widely used to treat inner ear disorders. While many substances are undergoing preclinical and clinical studies, it is equally important to develop appropriate drug delivery systems. Pharmacokinetic studies are technically demanding in animals and almost impossible in humans. Computer simulations have helped establish ...

Edfeldt, L. 2013. Middle Ear Cholesteatoma: Surgical Treatment, Follow-up and Hearing Restoration. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 905. 48 pp. Uppsala. ISBN 978-91-554-8672-3. Although middle-ear cholesteatoma is a major topic in otological research, its etiology and pathogenesis remain unclear. Pediatric chol...

Recent JT-60U experimental results toward establishment of advanced tokamak operation are reviewed with emphasis on the further expansion of the operational regime of AT plasmas using improved flexibility of NBIs by the modification of power supply and on the investigation of important issues for the establishment of steady-state AT operation using new diagnostics and improved heating systems. ...

1299 www.drugdiscoverytoday.com In recent years there has been increasing interest in the treatment of inner-ear disorders by local rather than systemic application of drugs. Substances are applied intratympanically, which means they are injected into the middle-ear cavity. This procedure is based on the premise that the drug will contact the round window membrane (RWM) of the cochlea, enter th...

Measurements of drug levels in the fluids of the inner ear are required to establish kinetic parameters and to determine the influence of specific local delivery protocols. For most substances, this requires cochlear fluids samples to be obtained for analysis. When auditory function is of primary interest, the drug level in the perilymph of scala tympani (ST) is most relevant, since drug in thi...

The perception of the effectiveness of instrumental actions is influenced by depressed mood. Depressive realism (DR) is the claim that depressed people are particularly accurate in evaluating instrumentality. In two experiments, the authors tested the DR hypothesis using an action–outcome contingency judgment task. DR effects were a function of intertrial interval length and outcome density, su...

Tadpoles involved in predator-prey interactions were studied in tropical wet forest in Costa Rica under laboratory and field conditions. Larvae of the frog Leptodactylus pentadactylas and naiads of the odonate Pantala flavescens are important predators on larvae of several species of frogs. The predators discriminate the prey on the basis of size and species, but not type of habitat in which pr...

season, while potentially costly, could significantly increase NUE. Current nitrogen use efficiency (NUE) of cereal crop production Recently, methods for estimating winter wheat N reis estimated to be near 33%, indicating that much of the applied quirements based on early season estimates of N uptake fertilizer N is not utilized by the plant and is susceptible to loss from and potential yield w...

Many vegetable production regions in the southwestern US are strictly regulated on water use. In addition, demand for high quality and nutritious vegetables has increased. This study was performed to explore the effects of deficit irrigation on yield, fruit quality and lycopene content of red-fleshed diploid and triploid watermelon (Citrullus lanatus (Thunb) Matsum & Nakai) cultivars. Irrigatio...