نتایج جستجو برای: rtk

تعداد نتایج: 2049  

2006
Chris Rizos

This paper reviews the establishment of GPS continuously operating reference stations (CORS) by government agencies and research institutes over the last two decades. The justification for the establishment of CORS networks was initially in support of geodesy and other geoscientific applications, at the global and regional level. However, increasingly GPS CORS network operators have sought ways...

Journal: :Journal of Global Positioning Systems 2006

Journal: :Molecular cancer therapeutics 2006
Shem Patyna A Douglas Laird Dirk B Mendel Anne-Marie O'farrell Chris Liang Huiping Guan Tomas Vojkovsky Stefan Vasile Xueyan Wang Jeffrey Chen Maren Grazzini Cheng Y Yang Joshua O Haznedar Juthamas Sukbuntherng Wei-Zhu Zhong Julie M Cherrington Dana Hu-Lowe

Receptor tyrosine kinases (RTK), such as vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), stem cell factor receptor (KIT), and fms-like tyrosine kinase 3 (FLT3), are expressed in malignant tissues and act in concert, playing diverse and major roles in angiogenesis, tumor growth, and metastasis. With the exception of a few malignancies, seemin...

2016
Yuka Hirashita Yoshiyuki Tsukamoto Kazuyoshi Yanagihara Shoichi Fumoto Naoki Hijiya Chisato Nakada Tomohisa Uchida Keiko Matsuura Masaaki Kodama Tadayoshi Okimoto Tsutomu Daa Masataka Seike Hidekatsu Iha Kuniaki Shirao Kazunari Murakami Masatsugu Moriyama

Gastric cancer (GC) is characterized by amplifications of receptor tyrosine kinases (RTK) and KRAS, therefore, targeting of the RTK/KRAS downstream pathways could help to broaden the applicability of molecular targeted therapy for GC. We assembled a panel of 48 GC cell lines and screened predictors of responsiveness to inhibition of the RAF/MEK/ERK pathway, one of the RTK/KRAS downstream pathwa...

Journal: :Biochimica Et Biophysica Acta - Reviews On Cancer 2021

Receptor Tyrosine Kinases (RTK) are an important family involved in numerous signaling pathways essential for proliferation, cell survival, transcription or cell-cycle regulation. Their role and involvement cancer survival have been widely described the literature, generally associated with overexpression and/or excessive activity pathology. Because of these characteristics, RTKs relevant targe...

Journal: :Molecular cancer research : MCR 2008
Fabienne Jäggi Miguel A Cabrita Anne-Karina T Perl Gerhard Christofori

Sprouty (Spry) proteins modulate signal transduction pathways elicited by receptor tyrosine kinases (RTK). Depending on cell type and the particular RTK, Spry proteins exert dual functions: They can either repress RTK-mediated signaling pathways, mainly by interfering with the Ras/Raf/mitogen-activated protein kinase pathway or sustaining RTK signal transduction, for example by sequestering the...

Journal: :Oncotarget 2016
Setareh Safavi Sofia Järnum Christoffer Vannas Sameer Udhane Emma Jonasson Tajana Tesan Tomic Pernilla Grundevik Henrik Fagman Magnus Hansson Zeynep Kalender Alexandra Jauhiainen Soheila Dolatabadi Eva Wessel Stratford Ola Myklebost Mikael Eriksson Göran Stenman Regine Schneider-Stock Anders Ståhlberg Pierre Åman

Myxoid sarcoma (MLS) is one of the most common types of malignant soft tissue tumors. MLS is characterized by the FUS-DDIT3 or EWSR1-DDIT3 fusion oncogenes that encode abnormal transcription factors. The receptor tyrosine kinase (RTK) encoding RET was previously identified as a putative downstream target gene to FUS-DDIT3 and here we show that cultured MLS cells expressed phosphorylated RET tog...

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