BACKGROUND Elderly patients with end-stage renal disease and severe extra-renal comorbidity have a poor prognosis on renal replacement therapy (RRT) and may opt to be managed conservatively (CM). Information on the survival of patients on this mode of therapy is limited. METHODS We studied survival in a large cohort of CM patients in comparison to patients who received RRT. RESULTS Over an ...

BACKGROUND Acute renal failure (ARF) occurs in up to 10% of critically ill patients, with significant associated morbidity and mortality. The optimal mode of renal replacement therapy (RRT) remains controversial. This retrospective study compared continuous renal replacement therapy (CRRT) and intermittent hemodialysis (IHD) for RRT in terms of intensive care unit (ICU) and hospital mortality, ...

We present RRT, the first asymptotically optimal samplingbased motion planning algorithm for real-time navigation in dynamic environments (containing obstacles that unpredictably appear, disappear, and move). Whenever obstacle changes are observed, e.g., by onboard sensors, a graph rewiring cascade quickly updates the search-graph and repairs its shortest-path-to-goal subtree. Both graph and tr...

In this paper we introduce a novel RRT extend function for wheeled mobile robots. The approach computes closed-loop forward simulations based on the kinematic model of the robot and enables the planner to efficiently generate smooth and feasible paths that connect any pairs of states. We extend the control law of an existing discontinuous state feedback controller to make it usable as an RRT ex...

Optimal path planning refers to find the collision free, shortest, and smooth route between start and goal positions. This task is essential in many robotic applications such as autonomous car, surveillance operations, agricultural robots, planetary and space exploration missions. Rapidly-exploring Random Tree Star (RRT*) is a renowned sampling based planning approach. It has gained immense pop...

BACKGROUND Critically ill patients requiring renal replacement therapy (RRT) are at risk of disease-related bleeding. Systemic heparinization should be avoided. AN69ST, a polyethyleneimine-treated polyacrylonitrile (AN69) membrane hemofilter, can be primed with heparin, improving its local anticoagulative activity. Prolonged intermittent RRT (PI-RRT) is of shorter duration and cheaper, consider...

INTRODUCTION In this cohort study, we explored the relationship between fluid balance, intradialytic hypotension and outcomes in critically ill patients with acute kidney injury (AKI) who received renal replacement therapy (RRT). METHODS We analysed prospectively collected registry data on patients older than 16 years who received RRT for at least two days in an intensive care unit at two uni...

BACKGROUND Perioperative complication of end-organ injury including acute kidney injury (AKI) is a frequent and severe problem for patients undergoing left ventricular assist device (LVAD) implantation. This study evaluated an emerging AKI biomarker, plasma neutrophil gelatinase-associated lipocalin (NGAL), in a LVAD implantation cohort. METHODS AND RESULTS Of 31 LVAD implantation patients en...

BACKGROUND Radiocontrast-induced nephropathy (RCIN) is an important cause of acute kidney injury, increasing in-hospital and long-term mortality. It is controversial whether prophylactic renal replacement therapy (RRT) may reduce a patient's risk of RCIN when compared with standard medical therapy (SMT). METHODS We searched through PubMed and bibliographies of retrieved articles. Published st...

BACKGROUND In a retrospective case-note and computer database analysis we assessed the outcome of very elderly patients (> or = 75 years old) with end-stage renal disease (ESRD) on renal replacement therapy (RRT). METHODS Fifty-eight individuals aged 75 or over (group 1) commenced RRT between 1 January 1991 and 31 December 1995. Comparisons were made with other patients commencing RRT who wer...