BACKGROUND Meta-analyses including a limited number of patients and events are prone to yield overestimated intervention effect estimates. While many assume bias is the cause of overestimation, theoretical considerations suggest that random error may be an equal or more frequent cause. The independent impact of random error on meta-analyzed intervention effects has not previously been explored....

OBJECTIVES/HYPOTHESIS A "July effect" of increased complications when new trainees begin residency has been reported widely by the media. We sought to determine the effect of admission month on in-hospital mortality, complications, length of hospitalization, and costs for patients undergoing head and neck cancer (HNCA) surgery. STUDY DESIGN Retrospective cross-sectional study. METHODS Disch...

BACKGROUND Despite the increased burden of preterm birth and its complications, the dearth of care seeking data for preterm newborns remains a significant knowledge gap. Among preterm babies in rural Bangladesh, we examined: 1) determinants and patterns of care seeking, and 2) risk analysis for care-seeking from qualified and unqualified providers. METHOD Trained community health workers coll...

BACKGROUND In adults, RRR-alpha-tocopheryl acetate (natural vitamin E) has approximately twice the biological activity of all-rac-alpha-tocopherol (synthetic vitamin E). Similar studies have not been done in term infants. OBJECTIVE We evaluated the vitamin E and antioxidant status of term infants fed formulas differing in the amount and form of vitamin E acetate. DESIGN A controlled, blinde...

The purpose of this study was to determine the association between common clinical features in general practice, and chest radiographic findings among children with suspected bacterial or viral pneumonia. The study was prospective hospital-based carried out in Northern Thailand, from 2000 to 2001. One thousand three hundred ninety-six children under age five years admitted with suspected pneumo...

Chronic widespread pain (CWP) is associated with poor health-related quality of life (HRQoL). It is unclear whether pain itself is the cause of poor HRQoL or other factors play a role. We hypothesised that new onset of CWP was associated with poor physical and mental HRQoL but that psychosocial risk markers for CWP onset would explain this relationship. A prospective population-based survey mea...

Within the emerging domain of entrepreneurial leadership research, gender issues have been largely ignored. This study aims to examine nexus between leader identity, passion, and growth intention. is done within stacked context being a woman entrepreneur, in rural, regional remote (RRR) Australia. unique draws upon cross-sectional survey 99 women entrepreneurs, employing partial least square st...

BACKGROUND This analysis compared the efficacy and safety outcomes by histology of nab-paclitaxel (nab-P) plus carboplatin (C) versus solvent-based paclitaxel (sb-P) plus C in patients with advanced non-small-cell lung cancer (NSCLC) based on preplanned stratification factors specified in the phase III trial protocol. PATIENTS AND METHODS Patients with untreated stage III/IV NSCLC received 10...

MAIN RESULTS 47 trials (25 randomised controlled trials [RCTs], n=59 566) met the selection criteria. (1) Influenza vaccine (inactivated parenteral vaccine [IP], live aerosol vaccine [LA], or inactivated aerosol vaccine [IA]) v placebo. Rates of CDI and SCI were lower in the IP group than in the placebo group (table). Rates of specified CDI and SCI were also lower in the LA group than in the pl...

OBJECTIVES Multiple systematic reviews have evaluated fluorides for caries prevention in children, but a need to review the literature regarding supplemental fluoride use in adults still remains. The purpose of this systematic review is to evaluate the research regarding professional and/or supplemental self-applied fluoride for preventing and remineralizing caries in moderate and high caries r...