BACKGROUND DREAM (Downstream Regulatory Element Antagonistic Modulator) is a neuronal calcium sensor that was suggested to modulate TSH receptor activity and whose overexpression provokes an enlargement of the thyroid gland in transgenic mice. The aim of this study was to investigate somatic mutations and DREAM gene expression in human multinodular goiter (MNG). MATERIAL AND METHODS DNA and RNA...

Bisphenol A (BPA) occurs widely in natural waters with both traditional and reproductive toxicity to various aquatic species. The water quality criteria (WQC), however, have not been established in China, which hinders the ecological risk assessment for the pollutant. This study therefore aims to derive the water quality criteria for BPA based on both acute and chronic toxicity endpoints and to...

The aim of this study was to evaluate the usefulness of quantitative real-time PCR (RQ-PCR) for the monitoring of molecular remission in follicular lymphoma (FL) patients during long-term follow-up. RQ-PCR by the use of TaqMan detection system is a sensitive tool to monitor minimal residual disease (MRD) in FL through amplification of the t(14;18) fusion gene during and post-therapy. In most ca...

BACKGROUND We aimed to evaluate the feasibility of using the allele burden of Janus kinase 2 (JAK2) V617F as a criterion for discriminating 3 subtypes of Philadelphia chromosome-negative myeloproliferative neoplasm (Ph(-)MPN): polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). METHODS We collected 70 peripheral blood (PB) and 81 bone marrow (BM) samples f...

Copyright is held by the author/owner(s). CHI 2011, May 7-12. Vancouver, Canada ACM 978-1-4503-0268-5/11/05. Abstract A significant portion of a user’s digital past is recorded in textual form, for example, in email messages, SMS texts, tweets, status updates and blog posts. We view this text archive as a personal informatics system that captures deep and meaningful information for the user. Ho...

In this paper we study the self-intersection of paths solving elliptic stochastic differential equations driven by fractional Brownian motion. We show that such a path has no – except for forming set zero (r,q)-capacity in sample space provided dimension d and Hurst parameter H satisfy inequality d>rq+2∕H. This is sharp case brownian motion according to existing results. Various results exist c...

We obtain an almost everywhere quantifier elimination for (the noncritical fragment of) the logic with probability quantifiers, introduced by the first author in [9]. This logic has quantifiers like ∃≥3/4y, which says that “for at least 3/4 of all y”. These results improve upon the 0-1 law for a fragment of this logic obtained by Knyazev [11]. Our improvements are: 1. We deal with the quantifie...

BACKGROUND The methodological quality and completeness of reporting of the systematic reviews (SRs) is fundamental to optimal implementation of evidence-based health care and the reduction of research waste. Methods exist to appraise SRs yet little is known about how they are used in SRs or where there are potential gaps in research best-practice guidance materials. The aims of this study are t...

The objective of this study was to validate use of the washed rumen (WR) technique for rapid measurement of fasting heat production (HP) and respiratory quotient (RQ). Sixteen Holstein steers were divided into 2 groups of 8 for a comparison of measurements made during feeding (both groups; 16 steers) and fasting (8 steers; BW = 237 ± 17 kg) and using the WR model (8 steers; BW = 322 ± 30 kg). S...