BACKGROUND Acute diarrhea is the second leading cause of mortality among children under 5 years of age in developing countries. The pathogen most strongly associated with diarrhea is rotavirus followed by enteric pathogens such as bacteria, helminthes and protozoan. Adequate sanitation and water supply contribute to decrease acute diarrhea incidence of most etiologic agents, although vaccinatio...

Over the past several years, a number of studies have clarified aspects of rotavirus immunology and vaccinology previously considered controversial. In this review, studies that address the following questions will be summarized: Which host factors are responsible for recovery from acute rotavirus infection? Are the host factors responsible for recovery from acute infection the same as those ne...

Intestinal intussusception is an uncommon event (incidence approximately 30 per 100 000 per year in US infants) in which one part of the intestine folds into another. The condition is usually considered idiopathic, but numerous case reports link intussusception to enteric pathogens, notably adenovirus. Several case reports have linked wild-type rotavirus to intussusception, although evidence fo...

Understanding how immunity shapes the dynamics of multistrain pathogens is essential in determining the selective pressures imposed by vaccines. There is currently much interest in elucidating the strain dynamics of rotavirus to determine whether vaccination may lead to the replacement of vaccine-type strains. In developed countries, G1P[8] strains constitute the majority of rotavirus infection...

Neutralizing antibody titers to four bovine rotavirus strains, representing three serotypes, were measured in 160 sera from cattle of different age groups. Age-specific seroprevalence analysis revealed serotype 6, represented by bovine rotavirus (BRV) NCDV, as the predominant rotavirus serotype infecting German cattle and serotype 10, represented by BRV V1005, as the least prominent. Infections...

Rotavirus is one of the main causes of acute gastroenteritis in infants and young children. Furthermore, rotavirus is the leading cause of hospitalization and death from acute gastroenteritis among infants and young children worldwide. Although death due to rotavirus is rare in industrialized regions such as Spain, the rotavirus disease burden and its economic impact is severe. This study aims ...

Rotavirus is a major cause of infectious intestinal disease in young children; a substantial prevalence of asymptomatic infection has been reported across all age groups. In this study, the authors determined characteristics of asymptomatic rotavirus infection and potential risk factors for infection. Healthy persons were recruited at random from the general population of England during the Stu...

Experimental or naturally acquired subclinical infections with rotavirus caused a significant increase in mortality of infant mice after challenge with enterotoxigenic Escherichia coli B44.

INTRODUCTION Diarrhoea continues to cause significant morbidity in Egypt. AIM To determine the frequency and distribution of different enteropathogens in acute diarrhoeal episodes, utilising an expanded testing regimen, and to correlate clinical signs and symptoms associated with the detected pathogens. MATERIAL AND METHODS The case-control study enrolled 356 patients < 5 years old with acu...

The clinical features of benign convulsions with mild gastroenteritis (CwG) were studied retrospectively in 62 patients hospitalized (Jan 2000-March 2006) at St Mary's Hospital, Kurume City, Japan. Viral infections confirmed in 71% of fecal specimens were rotavirus in 30 patients, norovirus in 9, sapovirus in 2, adenovirus in 2, and coxsackievirus A4 in 1. Age of patients with norovirus (16.7 +...