Cajal-Retzius (CR) cells play a key role in the formation of the cerebral cortex. These pioneer neurons are distributed throughout the cortical marginal zone in distinct graded distributions. Fate mapping and cell lineage tracing studies have recently shown that CR cells arise from restricted domains of the pallial ventricular zone, which are associated with signalling centres involved in the e...

In limbed vertebrates, the capacity to generate rhythmic motor patterns for locomotion and scratching is distributed over spinal cord segments of the limb enlargement (e.g., lumbosacral segments), but within this region, rostral segments are more rhythmogenic than caudal segments. The underlying reasons for this rostrocaudal asymmetry are not clear. One possibility is that rostral and caudal se...

Rostral prefrontal cortex (PFC) is known to be involved in source memory, the ability to recollect contextual information about an event. However it is unclear whether subregions of rostral PFC may be differentially engaged during the recollection of different kinds of source detail. We used event related functional MRI to contrast two forms of source recollection: (1) recollection of whether s...

We compared the electrophysiological properties of neurons in the rostral ventrolateral medulla of neonatal angiotensin II type 1a receptor knockout mice and wild-type mice with responses to angiotensin II, its type-1 receptor blocker candesartan, and its type-2 receptor blocker PD123319. Using the whole-cell patch-clamp technique, we examined the characteristics of rostral ventrolateral medull...

Spherical and globular bushy cells of the AVCN receive huge auditory nerve endings specialized for high fidelity neural transmission in response to acoustic events. Recent studies in mice and other rodent species suggest that the distinction between bushy cell subtypes is not always straightforward. We conducted a systematic investigation of mouse bushy cells along the rostral-caudal axis in an...

Rostral segments of the spinal cord hindlimb enlargement are more important than caudal segments for generating locomotion and scratching rhythms in limbed vertebrates, but the adequacy of rostral segments has not been directly compared between locomotion and scratching. We separated caudal segments from immobilized low-spinal turtles by sequential spinal cord transections. After separation of ...

Patients who have undergone surgical hemi/segmental/subtotal mandibulectomy for various reasons with resulting mandibular deviation are given a guide flange. If secondary osseous grafting is planned, the doctor must wait graft, lesion, or radiotherapeutic effects to resolve. A definitive prosthesis can be planned only when graft has been healed. During this time lag, patient fitted rectify caus...

BACKGROUND Mandibular resection for oral cancer is often necessary to achieve an adequate margin of tumor clearance. Segmental mandibulectomy has been associated with a poor health-related quality of life (HRQOL), particularly before composite free tissue transfer to reconstruct the defect. Little is published in the literature contrasting the subjective deficit of segmental compared with rim r...

BACKGROUND Plate-related complications following head and neck cancer ablation and reconstruction remains a challenging problem often requiring further management and reconstructive surgeries. We aim to identify an association between surgical site infections (SSI) and plate exposure. METHODS A retrospective study between 1997 and 2014 was performed to study the association between postoperat...

Despite the classically held belief of an "all-or-none" activation of the sympathetic nervous system, differential responses in sympathetic nerve activity (SNA) can occur acutely at varying magnitudes and in opposing directions. Sympathetic nerves also appear to contribute differentially to various disease states including hypertension and heart failure. Previously we have reported that sedenta...