Sex is pervasive throughout eukaryotes, yet many species have not been caught in the act. Now, a sexual cycle has been discovered in the choanoflagellate Salpingoeca rosetta, a pre-metazoan evolutionary model, opening a window on metazoan sexual evolution.

Keywords: Groundwater seepage Pedotransfer function ROSETTA Seepage erosion Uncertainty analysis s u m m a r y Research has suggested that streambank seepage can be an important mechanism of bank instability; however, limited information is available on the level of soil characterization necessary to accurately predict seepage gradient forces and erosion. The objective of this research was to q...

One of the key challenges in computational biology is prediction of three-dimensional protein structures from amino-acid sequences. For most proteins, the "native state" lies at the bottom of a free-energy landscape. Protein structure prediction involves varying the degrees of freedom of the protein in a constrained manner until it approaches its native state. In the Rosetta protein structure p...

Rosetta is an ESA cornerstone mission that will reach the comet 67P/Churyumov-Gerasimenko in 2014 and will escort the comet for approximately 1 year offering the most detailed study of a comet ever undertaken by humankind. The Rosetta orbiter has 11 scientific instruments (4 remote sensing) and the Philae lander to make complementary measurements of the comet nucleus, coma (gas and dust), and s...

Extreme-scale integration of modern system-on-chip (SoC) and escalating design complexity of emerging applications reiterate the importance of designing at a higher level of abstraction and call for an everimproving suite of high-level synthesis (HLS) tools to enable optimization opportunities that are otherwise infeasible at the register-transfer level (RTL) [1]. The need for software programm...

We describe predictions of the structures of CASP5 targets using Rosetta. The Rosetta fragment insertion protocol was used to generate models for entire target domains without detectable sequence similarity to a protein of known structure and to build long loop insertions (and N-and C-terminal extensions) in cases where a structural template was available. Encouraging results were obtained both...

Sampling alternative conformations is key to understanding how proteins work and engineering them for new functions. However, accurately characterizing and modeling protein conformational ensembles remain experimentally and computationally challenging. These challenges must be met before protein conformational heterogeneity can be exploited in protein engineering and design. Here, as a stepping...