Nanocellulose–oligoproline hydrogels, able to respond high levels of ROS and protect cells from oxidative environments, are promising candidates for the treatment chronic wounds other clinical conditions associated with ROS.

Abstract Reactive oxygen species (ROS) are naturally produced compounds that play important roles in cell signaling, gene regulation, and biological defense, including involvement the oxidative burst is central to anti-microbial actions of macrophages. However, these highly reactive, short-lived radical also stimulate cells undergo programmed death at high concentrations, as well causing detrim...

Anticancer drug delivery strategies are designed to take advantage of the differential chemical environment in solid tumors independently, or high levels reactive oxygen species (ROS) low pH, compared healthy tissue. Here, design and thorough characterization two functionalizable “AND gate” multiresponsive (MR) block amphiphilic copolymers reported, aimed full coexistence cues—ROS pH—present tu...

Elevated levels of reactive oxygen species (ROS) play a critical role in cardiac myocyte signaling in both healthy and diseased cells. Mitochondria represent the predominant cellular source of ROS, specifically the activity of complexes I and III. The model presented here explores the modulation of electron transport chain ROS production for state 3 and state 4 respiration and the role of subst...

ROS kinase is one of the last two remaining orphan receptor tyrosine kinases with an as yet unidentified ligand. The normal functions of human ROS kinase in different body tissues have not been fully identified so far. However, the ectopic expression, as well as the production of variable mutant forms of ROS kinase has been reported in a number of cancers, such as glioblastoma multiforme, and n...

Intracerebral hemorrhage is an emerging major health problem often resulting in death or disability. Reactive oxygen species (ROS) have been identified as one of the major damaging factors in ischemic stroke. However, there is less discussion about ROS in hemorrhage stroke. Metabolic products of hemoglobin, excitatory amino acids, and inflammatory cells are all sources of ROS, and ROS harm the ...

Several reactive oxygen species (ROS) are continuously produced in plants as byproducts of aerobic metabolism. Depending on the nature of the ROS species, some are highly toxic and rapidly detoxified by various cellular enzymatic and nonenzymatic mechanisms. Whereas plants are surfeited with mechanisms to combat increased ROS levels during abiotic stress conditions, in other circumstances plant...

Reactive oxygen species (ROS) play a key signal transduction role in cells. They are involved in the regulation of growth, development, responses to environmental stimuli and cell death. The level of ROS in cells is determined by interplay between ROS producing pathways and ROS scavenging mechanisms, part of the ROS gene network of plants. Recent studies identified respiratory burst oxidase hom...

The proto-oncogene tyrosine kinase c-ROS is an orphan receptor whose normal expression pattern is tightly spatio-temporally restricted during development. In glioma, c-ROS mRNA expression is frequently ectopically up-regulated. In this study, we determined by immunohistochemical means that c-ROS receptor protein is present in 25% of low-grade and 30% of malignant glioma tumor samples from tissu...

Over the last decade our understanding of the role of ROS has progressed from the classical view of adverse toxic metabolic byproducts inadvertently associated with aerobic life to include the newly emerging role of signaling molecules regulating growth, development and coordinating responses to abiotic and biotic stress. A recent series of discoveries have given scientists new insights into RO...