Receiver operating characteristic (ROC) analysis provides the most comprehensive description of diagnostic accuracy available to date, because it estimates and reports all of the combinations of sensitivity and specificity that a diagnostic test is able to provide. After sketching the 6 levels at which diagnostic efficacy can be assessed, this paper explains the conceptual foundations of conven...

Risk stratification is most directly and informatively summarized as a risk distribution curve. From this curve the ROC curve, predictiveness curve, and other curves depicting risk stratification can be derived, demonstrating that they present similar information. A mathematical expression for the ROC curve AUC is derived which clarifies how this measure of discrimination quantifies the overlap...

We aimed to compare the performance of three different individual ROC methods (one from each of the broad categories of parametric, nonparametric and semiparametric analysis) for assessing continuous diagnostic tests: the binormal method as a parametric method, an empirical approach as a nonparametric method, and a semiparametric method using generalized linear models (GLM). We performed a simu...

ROC analysis is a standard method for estimating and comparing diagnostic tests’ accuracies when the gold standard is binary. However, there are many situations when the gold standard is not binary. In these situations, traditional ROC methods applied have lead to biased and uninformative outcomes. This article introduces nonbinROC, software for R that implements nonparametric estimators propos...

Receiver operating characteristic (ROC) curves have application in analysis of the performance of diagnostic indicators used in the assessment of disease risk in clinical and veterinary medicine and in crop protection. For a binary indicator, an ROC curve summarizes the two distributions of risk scores obtained by retrospectively categorizing subjects as cases or controls using a gold standard....

OBJECTIVE To investigate the significance of C-reactive protein (CRP) in the discrimination of acute appendicitis pathology and its guiding role in the timing of surgery. METHODS 307 patients in our hospital from July 2012 to December 2013 were selected, who received appendectomy and simultaneous detections of WBC, neutrophil percentage and CRP; and Logistic regression analysis and Roc analys...

Objective To investigate the diagnostic value of cross-sectional area (CSA) and wrist to forearm ratio (WFR) in patients with electro-diagnosed carpal tunnel syndrome (CTS) with or without diabetes mellitus (DM). Methods We retrospectively studied 256 CTS wrists and 77 healthy wrists in a single center between January 1, 2008 and January 1, 2013. The CSA and WFR were calculated for each wrist...

We aimed to compare the minimum p value method and the area under the receiver operating characteristics (ROC) curve approach to categorize continuous biomarkers for the prediction of postoperative 30-day major adverse cardiac events in noncardiac vascular surgery patients. Individual-patient data from six cohorts reporting B-type natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic p...

ISSN 2277 5048 | © 2012 Bonfring Abstract--In recent years the Receiver Operating Characteristic (ROC) curves received much attention in medical diagnosis for classifying the subjects into one of the two groups. Many researchers have provided the mathematical formulation of the curve by assuming some specific distribution. Conventionally, much work has been carried out by assuming normal distri...