نتایج جستجو برای: rna structure
تعداد نتایج: 1783253 فیلتر نتایج به سال:
The Hopkins Lecturer is given the charge of explaining how advances in other fields of science have had an impact on his or her own field of biochemistry. A moment’s thought revealed that it was not at all difficult to think of examples where other scientific fields have provided necessary groundwork for the study of RNA catalysis or RNA biochemistry in general. Rather, it was difficult to choo...
The three-dimensional structures of RNAs are notoriously difficult to determine. Functional comparisons of variant molecules and cross-linking experiments are providing new information for structural modeling.
The Vienna RNA secondary structure server provides a web interface to the most frequently used functions of the Vienna RNA software package for the analysis of RNA secondary structures. It currently offers prediction of secondary structure from a single sequence, prediction of the consensus secondary structure for a set of aligned sequences and the design of sequences that will fold into a pred...
Motivated by the observation, that RNA folding gives rise to extended neutral networks in sequence space, concepts of random graph theory are applied to build a model of RNA sequence to structure mappings. This model allows to investigate generic properties of sequence-structure relations as well as the effect of neutrality. The random mapping construction is based on two tunable parameters. Th...
The crystal structures of the ribosome and its subunits have increased the amount of information about RNA structure by about two orders of magnitude. This is leading to an understanding of the principles of RNA folding and of the molecular interactions that underlie the functional capabilities of the ribosome and other RNA systems. Nearly all of the possible types of RNA tertiary interactions ...
Despite the success of RNA secondary structure prediction for simple, short RNAs, the problem of predicting RNAs with long-range tertiary folds remains. Furthermore, RNA 3D structure prediction is hampered by the lack of the knowledge about the tertiary contacts and their thermodynamic parameters. Low-resolution structural modeling enables us to estimate the conformational entropies for a numbe...
RNA secondary structure prediction is an important problem studied extensively in the past three dacades. However, pseudoknots are usually excluded in RNA secondary structure prediction due to the hardness of examining all possible structures efficiently and model the energy correctly. Current algorithms on predicting structures with pseudoknots usually have extremely high resource requirements...
The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a catalog of available structural information for these three enzymes. Most structural data have been accumulated for Pol II and its functional complexes. These studies have provided insights into many aspects of th...
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