BACKGROUND Sodium channel blockers augment ST-segment elevation in the right precordial leads in patients undergoing Brugada-type electrocardiography (ECG). However, their effect on echocardiographic features is not known. We address this by assessing global and regional ventricular function using conventional Doppler and two- dimensional (2D) speckle tracking techniques. METHODS Thirty-one p...

BACKGROUND Progressive left ventricular (LV) dysfunction can be a major late complication in patients with chronic right ventricular pressure overload (eg, tetralogy of Fallot). Therefore, we examined LV function (serial echocardiography and ex vivo Langendorff) and histology in a model of infant pressure-load right ventricular hypertrophy (RVH). METHODS AND RESULTS Ten-day-old rabbits (n=6 p...

In order to see if changes in preload could be used to help assess left ventricular function, 24 patients with uncomplicated acute myocardial infarction (AMI) received plasma volume expansion (PVE). In eight patients (group A) cardiac index (CI) increased by 20% or more, and in 16 patients (group B) CI increased by less than 20% or decreased. By plotting left ventricular stroke-work index (LVSW...

BACKGROUND Patients with systemic ventricles of right ventricular morphology are at high risk of contractile dysfunction, the cause of which has not been fully elucidated. OBJECTIVE To assess whether ischaemia or infarction contributes to ventricular impairment in unoperated patients with uncomplicated congenitally corrected transposition of the great arteries (TGA) by studying myocardial per...

23. Parker J, West R, Case R, Chiong M: Temporal relationships of myocardial lactate metabolism, left ventricular function, and S-T segment depression during angina precipitated by exercise. Circulation 40: 97, 1969 24. Sharma B, Goodwin J, Raphael M, Steiner R, Rainbow R, Taylor S: Left ventricular angiography on exercise: a new method of assessing left ventricular function in ischemic heart d...

BACKGROUND Sickle-cell disease (SCD) is an inherited hemoglobin childhood disorder, frequently complicated by pulmonary hypertension and cardiac involvement. Cardiovascular events and complications are the leading cause of mortality and morbidity in patients with SCD. Tissue Doppler imaging and the myocardial performance index (Tei index), are simple indices for the assessment of the cardiac fu...

BACKGROUND Left ventricular enlargement and the development of chronic heart failure are potent predictors of survival in patients after myocardial infarction. Prospective studies relating progressive ventricular enlargement in individual patients to global and regional cardiac dysfunction and the onset of late chronic heart failure are not available. It was the aim of this study to define the ...

Experimental right ventricular pressure-overload hypertrophy in small mammals is associated with early muscle dysfunction, even before the onset of overt pump failure. Experimental results are quite heterogeneous regarding muscle function of the pressure hypertrophied left ventricle. Muscle dysfunction of the right or left ventricle, when found, may be causally related to alterations of myosin ...

The goal of this study was to determine the sensitivity and specificity Myocardial Performance Index (MPI)for assessment acute right ventricular Infraction. This a descriptive type cross-sectional study. carried out in Coronary Care Unit, Department Cardiology, Sir Salimulla Medical College, Mitford Hospital. After exclusion total 72 patients were included study, which 24 had inferior MI with R...

Since heart failure may occur in the setting of lung dysfunction and CO2 retention with only modest increases in cardiac work load, we questioned whether myocardial function is impaired by hypercapnic acidosis. To determine the influence of hypercapnic acidosis on right ventricular function, we measured the effects of acute (2 hours) and chronic (2 weeks) hypercapnic acidosis on right ventricul...