Because of its complex geometry, assessment of right ventricular (RV) function is more difficult than it is for the left ventricle (LV). Because gene-targeted mouse models of cardiomyopathy may involve remodeling of the right heart, the purpose of this study was to develop high-resolution functional magnetic resonance imaging (MRI) for in vivo quantification of RV volumes and global function in...

Background The left ventricle (LV) can tolerate pressure overload from hypertension or aortic stenosis for many years. In contrast, the right ventricle (RV) adapts to pulmonary hypertension only if this develops at birth, while in the adult heart severe and often fatal RV failure develops. We hypothesized that i) these divergent responses could be due to differences in myofiber architecture in ...

Septation is one of the surgical choices for double-inlet left ventricle, yet postoperative hemodynamics have not been well defined. We studied ventricular volume characteristics in 10 patients with double-inlet left ventricle before and after septation. Preoperative end-diastolic volume (EDV) of the ventricle was 291 +/- 111% (+/- SD) of normal and ejection fraction (EF) was 0.59 +/- 0.07. Pos...

AIMS Endurance training may be associated with arrhythmogenic cardiac remodelling of the right ventricle (RV). We examined whether myocardial dysfunction following intense endurance exercise affects the RV more than the left ventricle (LV) and whether cumulative exposure to endurance competition influences cardiac remodelling (including fibrosis) in well-trained athletes. METHODS AND RESULTS ...

OBJECTIVE To evaluate the structure-function relationships of the right ventricle (RV) and septum and determine if the helical ventricular band model would define fiber orientation for maximal force response. Implications were made for right ventricular function. METHODS The right ventricular free wall and biventricular septum were studied by inserting sonomicrometer crystals at different ang...

OBJECTIVE Obesity is associated with changes in both right (RV) and left (LV) ventricular morphology, but the biological basis of this finding is not well established. We examined whether adipokine levels were associated with RV morphology and function in a population-based multiethnic sample free of clinical cardiovascular disease. METHODS We examined relationships of leptin, resistin, TNF-α...

Right and left ventricular myocytes originate from different cellular progenitors; however, it is unknown whether these cells differ in their response to endotoxemia. We hypothesized that 1) the percentage of endotoxemic functional depression within the right ventricle (RV) would be smaller than that of the left ventricle; and 2) that better RV function would correlate with lower levels of righ...

We evaluated the pathophysiologic correlates of right ventricular (RV) thallium-201 (9°1Tl) visualization in three canine models: (1) acute RV pressure overload (RVPO) induced by acute constriction of the pulmonary artery; (2) acute RV volume overload (RVVO) induced by acute left-to-right atrial shunt; and (3) RV hypertrophy (RVH) induced by chronic constriction of the pulmonary artery. Thalliu...

Introduction Evaluations of right ventricle (RV) parameters are feasible using echocardiographic, nuclear, computed tomography and cardiovascular magnetic resonance (CMR) techniques but perfusion of the RV is not routinely assessed. Knowledge of blood flow to myocardium of the RV might be a useful parameter in the assessment of disease states. Such a measurement might yield important informatio...

Background Ebstein anomaly is a kind of congenital defect of tricuspid valve mainly affecting the right ventricle, recent evidence have suggested the LV geometry remodeling in patient with Ebstein anomaly due to potential RV-LV coupling. The aim of this study-we investigated the interaction between abnormal right ventricle and left ventricle and whether myocardial fibrosis is the basis of abnor...